TF Info Page for FOXP1 (Forkhead)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro Has a putative AT-hook

Description

Description: forkhead box P1 [Source:HGNC Symbol;Acc:HGNC:3823]
Entrez Summary This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000114861
External Link: CisBP
Interpro IPR001766; ;
Protein Domain: ENSP00000318721
Protein Domain: ENSP00000318902
Protein Domain: ENSP00000419393
Protein Domain: ENSP00000418225
Protein Domain: ENSP00000417857
Protein Domain: ENSP00000420736
Protein Domain: ENSP00000418524
Protein Domain: ENSP00000418102
Protein Domain: ENSP00000482847
Protein Domain: ENSP00000484963
Protein Domain: ENSP00000417941
Protein Domain: ENSP00000477918
Domain:
Protein: ENSP00000318721DBD: ForkheadOther:
Protein: ENSP00000318902DBD: ForkheadOther: FOXP-CC
Protein: ENSP00000419393DBD: ForkheadOther: FOXP-CC
Protein: ENSP00000418225DBD: ForkheadOther: FOXP-CC
Protein: ENSP00000417857DBD: ForkheadOther: FOXP-CC
Protein: ENSP00000420736DBD: ForkheadOther: FOXP-CC
Protein: ENSP00000418524DBD: ForkheadOther: FOXP-CC
Protein: ENSP00000418102DBD: ForkheadOther: FOXP-CC
Protein: ENSP00000482847DBD: ForkheadOther: FOXP-CC
Protein: ENSP00000484963DBD: ForkheadOther:
Protein: ENSP00000417941DBD: ForkheadOther: FOXP-CC
Protein: ENSP00000477918DBD: ForkheadOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:8265594 16819554
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
PBMZoo_01Direct
ChIP-seqJASPARDirect
TransfacTransfacLicense requiredDirect
MiscHOMERDirect
PBMDREAM_contestInferred - Foxp1 (100% AA Identity, Mus musculus)
SMiLE-seqIsakova2017Inferred - FOXP2 (88% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Foxp2 (88% AA Identity, Mus musculus)
ChIP-seqJASPARInferred - FOXP2 (88% AA Identity, Homo sapiens)
MiscHocoMocoInferred - FOXP2 (88% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - FoxP (73% AA Identity, Drosophila melanogaster)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution