The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:	BBX, HMG-box containing [Source:HGNC Symbol;Acc:HGNC:14422]
Entrez Summary	TBA
Ensembl ID:	ENSG00000114439
External Link:
Interpro	IPR009071; IPR019102;
Protein Domain:
Protein: ENSP00000319974	DBD: HMG	Other: DUF2028
Protein: ENSP00000408358	DBD: HMG	Other: DUF2028
Protein: ENSP00000403860	DBD: HMG	Other: DUF2028
Protein: ENSP00000400543	DBD: HMG	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	b
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
PBM	Badis09		Inferred - Bbx (98% AA Identity, Mus musculus)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "curved", "end": 148, "endStyle": "curved", "aliStart": 81, "text": "HMG", "colour": "#228B22", "aliEnd": 148, "start": 80, "href": "http://pfam.xfam.org/family/PF00505.17", "type": "pfama", "display": "true", "metadata": {"end": 148, "description": "High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms, and can be broadly divided into two groups, based on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif, while the latter can contain multiple HMG-box motifs.", "database": "PfamA", "aliStart": 81, "scoreName": "E-value", "accession": "PF00505.17", "start": 80, "score": 3.3e-17, "identifier": "HMG (high mobility group) box", "type": "DBD", "aliEnd": 148}}, {"startStyle": "straight", "end": 380, "endStyle": "jagged", "aliStart": 191, "text": "DUF2028", "colour": "#9999ff", "aliEnd": 350, "start": 191, "href": "http://pfam.xfam.org/family/PF09667.8", "type": "pfama", "display": "true", "metadata": {"end": 380, "description": "This region of similarity is found in the vertebrate homologues of the drosophila Bobby Sox.", "database": "PfamA", "aliStart": 191, "scoreName": "E-value", "accession": "PF09667.8", "start": 191, "score": 1.1e-54, "identifier": "Domain of unknown function (DUF2028)", "type": "DBD", "aliEnd": 350}}], "length": 942}

{"regions": [{"startStyle": "curved", "end": 148, "endStyle": "curved", "aliStart": 81, "text": "HMG", "colour": "#228B22", "aliEnd": 148, "start": 80, "href": "http://pfam.xfam.org/family/PF00505.17", "type": "pfama", "display": "true", "metadata": {"end": 148, "description": "High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms, and can be broadly divided into two groups, based on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif, while the latter can contain multiple HMG-box motifs.", "database": "PfamA", "aliStart": 81, "scoreName": "E-value", "accession": "PF00505.17", "start": 80, "score": 3.3e-17, "identifier": "HMG (high mobility group) box", "type": "DBD", "aliEnd": 148}}, {"startStyle": "straight", "end": 380, "endStyle": "jagged", "aliStart": 191, "text": "DUF2028", "colour": "#9999ff", "aliEnd": 350, "start": 191, "href": "http://pfam.xfam.org/family/PF09667.8", "type": "pfama", "display": "true", "metadata": {"end": 380, "description": "This region of similarity is found in the vertebrate homologues of the drosophila Bobby Sox.", "database": "PfamA", "aliStart": 191, "scoreName": "E-value", "accession": "PF09667.8", "start": 191, "score": 9.999999999999999e-55, "identifier": "Domain of unknown function (DUF2028)", "type": "DBD", "aliEnd": 350}}], "length": 912}

{"regions": [{"startStyle": "curved", "end": 148, "endStyle": "curved", "aliStart": 81, "text": "HMG", "colour": "#228B22", "aliEnd": 148, "start": 80, "href": "http://pfam.xfam.org/family/PF00505.17", "type": "pfama", "display": "true", "metadata": {"end": 148, "description": "High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms, and can be broadly divided into two groups, based on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif, while the latter can contain multiple HMG-box motifs.", "database": "PfamA", "aliStart": 81, "scoreName": "E-value", "accession": "PF00505.17", "start": 80, "score": 2e-17, "identifier": "HMG (high mobility group) box", "type": "DBD", "aliEnd": 148}}, {"startStyle": "straight", "end": 315, "endStyle": "jagged", "aliStart": 191, "text": "DUF2028", "colour": "#9999ff", "aliEnd": 305, "start": 191, "href": "http://pfam.xfam.org/family/PF09667.8", "type": "pfama", "display": "true", "metadata": {"end": 315, "description": "This region of similarity is found in the vertebrate homologues of the drosophila Bobby Sox.", "database": "PfamA", "aliStart": 191, "scoreName": "E-value", "accession": "PF09667.8", "start": 191, "score": 4.5e-52, "identifier": "Domain of unknown function (DUF2028)", "type": "DBD", "aliEnd": 305}}], "length": 629}

TF Info Page for BBX (HMG/Sox)