hes family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:5192]
Entrez Summary
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This protein belongs to the basic helix-loop-helix family of
transcription factors. It is a transcriptional repressor of genes that
require a bHLH protein for their transcription. The protein has a particular
type of basic domain that contains a helix interrupting protein that binds to
the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a ISS - GO_REF:0000024 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:17681138
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF