TF Info Page for TFDP2 (E2F)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Inferred motif | 2 Obligate heteromer | In vivo/Misc source |
Description
| Description: | transcription factor Dp-2 [Source:HGNC Symbol;Acc:HGNC:11751] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000114126 | |
| External Link: | ||
| Interpro | IPR003316; IPR014889; IPR015648; ; | |
| Protein Domain: | ||
| Protein: ENSP00000418590 | DBD: E2F | Other: |
| Protein: ENSP00000417585 | DBD: E2F | Other: |
| Protein: ENSP00000420599 | DBD: E2F | Other: |
| Protein: ENSP00000420616 | DBD: E2F | Other: |
| Protein: ENSP00000420657 | DBD: E2F | Other: |
| Protein: ENSP00000439782 | DBD: E2F | Other: |
| Protein: ENSP00000419507 | DBD: E2F | Other: |
| Protein: ENSP00000418971 | DBD: E2F | Other: |
| Protein: ENSP00000419036 | DBD: E2F | Other: |
| Protein: ENSP00000417726 | DBD: E2F | Other: |
| Protein: ENSP00000418122 | DBD: E2F | Other: |
| Protein: ENSP00000417220 | DBD: E2F | Other: |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene Candidate_Transcription Factor Binding tf co-factor binding_TF PPI Transactivation_ PMIDS:7478568 7784053 10090723 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA - GO_REF:0000033 GO:0003700 sequence-specific DNA binding transcription factor activity NAS - PMID:7784053 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
2a1, Lower confidence direct evidence |
| TF has conditional DNA-binding requirements | Obligate_Multimer |