The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Inferred motif	2 Obligate heteromer	In vivo/Misc source

Description

Description:

transcription factor Dp-2 [Source:HGNC Symbol;Acc:HGNC:11751]

Entrez Summary

The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Ensembl ID:

ENSG00000114126

External Link:

CisBP

Interpro

IPR003316; IPR014889; IPR015648; ;

Protein Domain:

ENSP00000418590

Protein Domain:

ENSP00000417585

Protein Domain:

ENSP00000420599

Protein Domain:

ENSP00000420616

Protein Domain:

ENSP00000420657

Protein Domain:

ENSP00000439782

Protein Domain:

ENSP00000419507

Protein Domain:

ENSP00000418971

Protein Domain:

ENSP00000419036

Protein Domain:

ENSP00000417726

Protein Domain:

ENSP00000418122

Protein Domain:

ENSP00000417220

Domain:

Protein: ENSP00000418590	DBD: E2F	Other:
Protein: ENSP00000417585	DBD: E2F	Other:
Protein: ENSP00000420599	DBD: E2F	Other:
Protein: ENSP00000420616	DBD: E2F	Other:
Protein: ENSP00000420657	DBD: E2F	Other:
Protein: ENSP00000439782	DBD: E2F	Other:
Protein: ENSP00000419507	DBD: E2F	Other:
Protein: ENSP00000418971	DBD: E2F	Other:
Protein: ENSP00000419036	DBD: E2F	Other:
Protein: ENSP00000417726	DBD: E2F	Other:
Protein: ENSP00000418122	DBD: E2F	Other:
Protein: ENSP00000417220	DBD: E2F	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene Candidate_Transcription Factor Binding tf co-factor binding_TF PPI Transactivation_ PMIDS:7478568 7784053 10090723
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA - GO_REF:0000033 GO:0003700 sequence-specific DNA binding transcription factor activity NAS - PMID:7784053
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements	Obligate_Multimer

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
Misc	HocoMoco		Inferred - TFDP1 (81% AA Identity, Homo sapiens)

Structure

Structure	PDB	1CF7

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for TFDP2 (E2F)

Conclusion

Description

Previous Annotations

DNA-Binding

Published Motif Data

Structure

Experimental History

External Contribution