TF Info Page for TFDP2 (E2F)


Assessment Binding Mode Motif Status Notes Comments
Inferred motif 2 Obligate heteromer In vivo/Misc source


Description: transcription factor Dp-2 [Source:HGNC Symbol;Acc:HGNC:11751]
Entrez Summary The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Ensembl ID: ENSG00000114126
External Link: CisBP
Interpro IPR003316; IPR014889; IPR015648; ;
Protein Domain: ENSP00000418590
Protein Domain: ENSP00000417585
Protein Domain: ENSP00000420599
Protein Domain: ENSP00000420616
Protein Domain: ENSP00000420657
Protein Domain: ENSP00000439782
Protein Domain: ENSP00000419507
Protein Domain: ENSP00000418971
Protein Domain: ENSP00000419036
Protein Domain: ENSP00000417726
Protein Domain: ENSP00000418122
Protein Domain: ENSP00000417220
Protein: ENSP00000418590DBD: E2FOther:
Protein: ENSP00000417585DBD: E2FOther:
Protein: ENSP00000420599DBD: E2FOther:
Protein: ENSP00000420616DBD: E2FOther:
Protein: ENSP00000420657DBD: E2FOther:
Protein: ENSP00000439782DBD: E2FOther:
Protein: ENSP00000419507DBD: E2FOther:
Protein: ENSP00000418971DBD: E2FOther:
Protein: ENSP00000419036DBD: E2FOther:
Protein: ENSP00000417726DBD: E2FOther:
Protein: ENSP00000418122DBD: E2FOther:
Protein: ENSP00000417220DBD: E2FOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate_Transcription Factor Binding
tf co-factor binding_TF PPI
PMIDS:7478568 7784053 10090723
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
sequence-specific DNA binding transcription factor activity
NAS - PMID:7784053
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements Obligate_Multimer


Published Motif Data

Source Annotation Motif Evidence
MiscHocoMocoInferred - TFDP1 (81% AA Identity, Homo sapiens)


Structure PDB 1CF7

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution