The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:	B-cell CLL/lymphoma 6 [Source:HGNC Symbol;Acc:HGNC:1001]
Entrez Summary	TBA
Ensembl ID:	ENSG00000113916
External Link:	T044291_1.02
Interpro	IPR000210; IPR007087; IPR011333; IPR013069; IPR015880; ;
Protein Domain:
Protein: ENSP00000232014	DBD: C2H2 ZF Containing Proteins	Other: BTB, DZR
Protein: ENSP00000384371	DBD: C2H2 ZF Containing Proteins	Other: BTB, DZR
Protein: ENSP00000413122	DBD: C2H2 ZF Containing Proteins	Other: BTB, DZR
Protein: ENSP00000415574	DBD: C2H2 ZF Containing Proteins	Other: BTB, DUF3342
Protein: ENSP00000414455	DBD: C2H2 ZF Containing Proteins	Other: BTB

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:12097386 15659391
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IEA - GO_REF:0000019 GO:0003700 sequence-specific DNA binding transcription factor activity IMP - PMID:15577913
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
PBM	Barrera2016		Direct
PBM	Barrera2016		Direct
HT-SELEX	Yin2017		Direct
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
ChIP-seq	hmCHIP		Inferred - Bcl6 (100% AA Identity, Mus musculus)
ChIP-seq	JASPAR		Inferred - Bcl6 (100% AA Identity, Mus musculus)
Misc	HOMER		Inferred - Bcl6 (100% AA Identity, Mus musculus)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for BCL6 (C2H2 ZF(non-KRAB))