TF Info Page for ZNF346 (C2H2 ZF)


Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 1 Monomer or homomultimer No motif Binds dsDNA with low affinity and no discernible specificity (PMID: 24521053).


Description: zinc finger protein 346 [Source:HGNC Symbol;Acc:HGNC:16403]
Entrez Summary The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Ensembl ID: ENSG00000113761
External Link: CisBP
Interpro IPR003604; IPR007087; IPR015880; ;
Protein Domain: ENSP00000350869
Protein Domain: ENSP00000424495
Protein Domain: ENSP00000421212
Protein Domain: ENSP00000423515
Protein Domain: ENSP00000421089
Protein: ENSP00000350869DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met
Protein: ENSP00000424495DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met
Protein: ENSP00000421212DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-U1, zf-met
Protein: ENSP00000423515DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met
Protein: ENSP00000421089DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_jaz, zf-met

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? No
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
5a, one of the source datasets predicts is as a TF
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution