TF Info Page for NR3C1 (Nuclear receptor)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description
| Description: | nuclear receptor subfamily 3 group C member 1 [Source:HGNC Symbol;Acc:HGNC:7978] | ||||||||||||||||||||||||||||||
| Entrez Summary | This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011] | ||||||||||||||||||||||||||||||
| Ensembl ID: | ENSG00000113580 | ||||||||||||||||||||||||||||||
| External Link: | CisBP | ||||||||||||||||||||||||||||||
| Interpro | IPR000536; IPR001409; IPR001628; IPR001723; IPR008946; ; | ||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000231509 | ||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000377977 | ||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000387672 | ||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000405282 | ||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000420856 | ||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000427672 | ||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000422518 | ||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000425313 | ||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000424747 | ||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000426478 | ||||||||||||||||||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:16728402 67253380 15563547 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:16728402, PMID:23823477 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:15769988, PMID:17635946 |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |