TF Info Page for IRX4 (Homeodomain)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | 100 perc ID - in vitro |
Description
| Description: | iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6129] | ||||||||||||||||||
| Entrez Summary | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within heart development. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] | ||||||||||||||||||
| Ensembl ID: | ENSG00000113430 | ||||||||||||||||||
| External Link: | CisBP | ||||||||||||||||||
| Interpro | IPR001356; IPR003893; IPR008422; IPR009057; IPR017970; ; | ||||||||||||||||||
| Protein Domain: | ENSP00000231357 | ||||||||||||||||||
| Protein Domain: | ENSP00000423161 | ||||||||||||||||||
| Protein Domain: | ENSP00000424235 | ||||||||||||||||||
| Protein Domain: | ENSP00000482393 | ||||||||||||||||||
| Protein Domain: | ENSP00000481396 | ||||||||||||||||||
| Protein Domain: | ENSP00000421772 | ||||||||||||||||||
| Domain: |
|
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene Candidate__Other_ PMIDS:10625552 11238910 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info | |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |