TF Info Page for SIM1 (bHLH)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Inferred motif 2 Obligate heteromer In vivo/Misc source Similar to SIM2, which is a likely obligate heteromer.

Description

Description: single-minded family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10882]
Entrez Summary SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000112246
External Link: CisBP
Interpro IPR000014; IPR001610; IPR010578; IPR011598; IPR013655; IPR013767;
Protein Domain: ENSP00000262901
Protein Domain: ENSP00000358210
Domain:
Protein: ENSP00000262901DBD: bHLHOther: PAS, PAS_11, PAS_3, PAS_4, PAS_9, SIM_C
Protein: ENSP00000358210DBD: bHLHOther: PAS, PAS_11, PAS_3, PAS_4, PAS_9, SIM_C

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
other
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:8812055, PMID:9199934
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a2, Orthologous HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredInferred - HIF1A (61% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - HIF1A (61% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - HIF1A (61% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - HIF1A (61% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - HIF1A (61% AA Identity, Homo sapiens)
MiscHocoMocoInferred - HIF1A (61% AA Identity, Homo sapiens)
MiscHOMERInferred - HIF1A (61% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EPAS1 (57% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EPAS1 (57% AA Identity, Homo sapiens)
MiscHocoMocoInferred - EPAS1 (57% AA Identity, Homo sapiens)
MiscHOMERInferred - EPAS1 (57% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Hif3a (51% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution