The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Likely to be sequence specific TF	1 Monomer or homomultimer	No motif

Description

Description:	zinc finger protein 451 [Source:HGNC Symbol;Acc:HGNC:21091]
Entrez Summary	TBA
Ensembl ID:	ENSG00000112200
External Link:
Interpro	IPR007087; IPR015880; IPR021623; ;
Protein Domain:
Protein: ENSP00000350083	DBD: C2H2 ZF Containing Proteins	Other: zf-C2H2_4
Protein: ENSP00000359740	DBD: C2H2 ZF Containing Proteins	Other: zf-C2H2_4
Protein: ENSP00000421645	DBD: C2H2 ZF Containing Proteins	Other: zf-C2H2_4
Protein: ENSP00000359736	DBD: C2H2 ZF Containing Proteins	Other:
Protein: ENSP00000359742	DBD: C2H2 ZF Containing Proteins	Other: LAP2alpha
Protein: ENSP00000359744	DBD: C2H2 ZF Containing Proteins	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0003700 sequence-specific DNA binding transcription factor activity IBA - GO_REF:0000033
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 790, "scoreName": "E-value", "accession": "PF00096.24", "start": 789, "score": 0.0085, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 812}}, {"startStyle": "straight", "end": 275, "endStyle": "straight", "aliStart": 253, "text": "zf-C2H2_4", "colour": "#9999ff", "aliEnd": 273, "start": 253, "href": "http://pfam.xfam.org/family/PF13894.4", "type": "pfama", "display": "true", "metadata": {"end": 275, "description": "This family contains a number of divergent C2H2 type zinc fingers.", "database": "PfamA", "aliStart": 253, "scoreName": "E-value", "accession": "PF13894.4", "start": 253, "score": 6.100000000000001e-11, "identifier": "C2H2-type zinc finger", "type": "DBD", "aliEnd": 273}}, {"startStyle": "jagged", "end": 493, "endStyle": "straight", "aliStart": 475, "text": "zf-C2H2_4", "colour": "#9999ff", "aliEnd": 491, "start": 473, "href": "http://pfam.xfam.org/family/PF13894.4", "type": "pfama", "display": "true", "metadata": {"end": 493, "description": "This family contains a number of divergent C2H2 type zinc fingers.", "database": "PfamA", "aliStart": 475, "scoreName": "E-value", "accession": "PF13894.4", "start": 473, "score": 6.100000000000001e-11, "identifier": "C2H2-type zinc finger", "type": "DBD", "aliEnd": 491}}, {"startStyle": "straight", "end": 628, "endStyle": "straight", "aliStart": 607, "text": "zf-C2H2_4", "colour": "#9999ff", "aliEnd": 626, "start": 606, "href": "http://pfam.xfam.org/family/PF13894.4", "type": "pfama", "display": "true", "metadata": {"end": 628, "description": "This family contains a number of divergent C2H2 type zinc fingers.", "database": "PfamA", "aliStart": 607, "scoreName": "E-value", "accession": "PF13894.4", "start": 606, "score": 6.100000000000001e-11, "identifier": "C2H2-type zinc finger", "type": "DBD", "aliEnd": 626}}, {"startStyle": "straight", "end": 659, "endStyle": "straight", "aliStart": 636, "text": "zf-C2H2_4", "colour": "#9999ff", "aliEnd": 659, "start": 636, "href": "http://pfam.xfam.org/family/PF13894.4", "type": "pfama", "display": "true", "metadata": {"end": 659, "description": "This family contains a number of divergent C2H2 type zinc fingers.", "database": "PfamA", "aliStart": 636, "scoreName": "E-value", "accession": "PF13894.4", "start": 636, "score": 6.100000000000001e-11, "identifier": "C2H2-type zinc finger", "type": "DBD", "aliEnd": 659}}, {"startStyle": "straight", "end": 776, "endStyle": "straight", "aliStart": 753, "text": "zf-C2H2_4", "colour": "#9999ff", "aliEnd": 776, "start": 753, "href": "http://pfam.xfam.org/family/PF13894.4", "type": "pfama", "display": "true", "metadata": {"end": 776, "description": "This family contains a number of divergent C2H2 type zinc fingers.", "database": "PfamA", "aliStart": 753, "scoreName": "E-value", "accession": "PF13894.4", "start": 753, "score": 6.100000000000001e-11, "identifier": "C2H2-type zinc finger", "type": "DBD", "aliEnd": 776}}], "length": 1014}

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TF Info Page for ZNF451 (C2H2 ZF(non-KRAB))