TF Info Page for PPARD (Nuclear receptor)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: peroxisome proliferator activated receptor delta [Source:HGNC Symbol;Acc:HGNC:9235]
Entrez Summary This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]
Ensembl ID: ENSG00000112033
External Link: CisBP
Interpro IPR000536; IPR001628; IPR001723; IPR003074; IPR003075; IPR008946;
Protein Domain: ENSP00000353916
Protein Domain: ENSP00000413314
Protein Domain: ENSP00000414372
Domain:
Protein: ENSP00000353916DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000413314DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000414372DBD: Nuclear Hormone ReceptorOther: Hormone_recep

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_Other_
PMIDS:11923467
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001227
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
ISS - GO_REF:0000024
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:12955147 | NAS - PMID:11551955
GO:0004879
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
IDA - PMID:12955147
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
MiscHocoMocoDirect
TransfacTransfacLicense requiredInferred - PPARA (85% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PPARA (85% AA Identity, Homo sapiens)
MiscHocoMocoInferred - PPARA (85% AA Identity, Homo sapiens)
MiscHocoMocoInferred - PPARA (85% AA Identity, Homo sapiens)
SMiLE-seqIsakova2017Inferred - Pparg (82% AA Identity, Mus musculus)
SELEXJASPARInferred - PPARG (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PPARG (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PPARG (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PPARG (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PPARG (82% AA Identity, Homo sapiens)
MiscHocoMocoInferred - PPARG (82% AA Identity, Homo sapiens)
MiscHocoMocoInferred - PPARG (82% AA Identity, Homo sapiens)
MiscHOMERInferred - Pparg (82% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution