cAMP responsive element binding protein like 2 [Source:HGNC Symbol;Acc:HGNC:2350]
Entrez Summary
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was
identified in a search to find genes in a commonly deleted region on
chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with
hematopoietic malignancies, as well as breast, non-small-cell lung and
ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB)
over a 48-base long region which encodes the bZip domain of CREB. The bZip
domain consists of about 30 amino acids rich in basic residues involved in
DNA binding, followed by a leucine zipper motif involved in protein
dimerization. This suggests that CREBL2 encodes a protein with DNA binding
capabilities. The occurance of CREBL2 deletion in malignancy suggests that
CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0003700 sequence-specific DNA binding transcription factor activity IEA - GO_REF:0000002
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF