TF Info Page for NFKB1 (Rel)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description
| Description: | nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000109320 | |
| External Link: | T138170_1.02 | |
| Interpro | IPR000451; IPR000488; IPR002110; IPR002909; IPR008967; IPR011029; IPR011539; IPR014756; IPR020683; IPR030492; | |
| Protein Domain: | ||
| Protein: ENSP00000226574 | DBD: RHD | Other: Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer |
| Protein: ENSP00000378297 | DBD: RHD | Other: Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer |
| Protein: ENSP00000424790 | DBD: RHD | Other: Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer |
| Protein: ENSP00000469340 | DBD: RHD | Other: Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer |
| Protein: ENSP00000424815 | DBD: RHD | Other: RHD_dimer |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:1406630 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv IDA - PMID:1406630 GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IDA - PMID:24434510 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:17426251 GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS - Reactome:R-HSA-445989 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |