TF Info Page for CAMTA2 (CG-1)


Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 1 Monomer or homomultimer No motif


Description: calmodulin binding transcription activator 2 [Source:HGNC Symbol;Acc:HGNC:18807]
Entrez Summary The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]
Ensembl ID: ENSG00000108509
External Link: CisBP
Interpro IPR000048; IPR002909; IPR005559; IPR014756; IPR020683; IPR027417;
Protein Domain: ENSP00000321813
Protein Domain: ENSP00000354828
Protein Domain: ENSP00000370712
Protein Domain: ENSP00000412886
Protein: ENSP00000321813DBD: CG-1Other: Ank_2, Ank_3, Ank_5, IQ, TIG
Protein: ENSP00000354828DBD: CG-1Other: Ank_2, Ank_3, Ank_5, IQ, TIG
Protein: ENSP00000370712DBD: CG-1Other: Ank_2, Ank_3, Ank_5, IQ, TIG
Protein: ENSP00000412886DBD: CG-1Other: Ank_2, Ank_3, Ank_5, IQ, TIG

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_Transcription Factor Binding
tf co-factor binding_Co-activation
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution