Only known motifs are from Transfac or HocoMoco - origin is uncertain
Description
Description:
early B-cell factor 3 [Source:HGNC Symbol;Acc:HGNC:19087]
Entrez Summary
This gene encodes a member of the early B-cell factor (EBF) family
of DNA binding transcription factors. EBF proteins are involved in B-cell
differentiation, bone development and neurogenesis, and may also function as
tumor suppressors. The encoded protein inhibits cell survival through the
regulation of genes involved in cell cycle arrest and apoptosis, and aberrant
methylation or deletion of this gene may play a role in multiple malignancies
including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq,
Sep 2011]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IBA - GO_REF:0000033
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF