This gene encodes a transcription factor that is a member of the
leucine zipper family of DNA binding proteins. This protein binds to the
cAMP-response element and regulates cell proliferation. The protein interacts
with host cell factor C1, which also associates with the herpes simplex virus
(HSV) protein VP16 that induces transcription of HSV immediate-early genes.
This protein and VP16 both bind to the same site on host cell factor C1. It
is thought that the interaction between this protein and host cell factor C1
plays a role in the establishment of latency during HSV infection. This
protein also plays a role in leukocyte migration, tumor suppression, and
endoplasmic reticulum stress-associated protein degradation. Additional
transcript variants have been identified, but their biological validity has
not been determined.[provided by RefSeq, Nov 2009]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:16940180 GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IMP - PMID:16940180
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF