Alias FLJ20420 can specially bind the hBAG-1 promoter region by EMSA and ChIP assays (PMID: 22567091)
Description
Description:
coiled-coil-helix-coiled-coil-helix domain containing 3 [Source:HGNC Symbol;Acc:HGNC:21906];MICOS co
Entrez Summary
The protein encoded by this gene is an inner mitochondrial membrane
scaffold protein. Absence of the encoded protein affects the structural
integrity of mitochondrial cristae and leads to reductions in ATP production,
cell growth, and oxygen consumption. This protein is part of the
mitochondrial contact site and cristae organizing system (MICOS). Several
transcript variants encoding different isoforms have been found for this
gene. [provided by RefSeq, Nov 2015]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
No
CisBP considers it as a TF?
No
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IDA - PMID:22567091
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
5a, one of the source datasets predicts is as a TF