POU class 6 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:21694]
Entrez Summary
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This gene encodes a member of the POU protein family characterized
by the presence of a bipartite DNA binding domain, consisting of a
POU-specific domain and a homeodomain, separated by a variable polylinker.
The DNA binding domain may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner. The POU family members are
transcriptional regulators, many of which are known to control cell
type-specific differentiation pathways. This gene is a tumor suppressor
involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript
variants encoding distinct isoforms have been found for this gene.[provided
by RefSeq, Oct 2009]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:8601806
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF