TF Info Page for HOXA5 (Homeodomain)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: homeobox A5 [Source:HGNC Symbol;Acc:HGNC:5106]
Entrez Summary In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000106004
External Link: CisBP
Interpro IPR001356; IPR001827; IPR009057; IPR017970; IPR017995; IPR020479;
Protein Domain: ENSP00000222726
Domain:
Protein: ENSP00000222726DBD: HomeodomainOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:10879542
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:10879542
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:10879542, PMID:16756717
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
COMPILEDJASPARDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMBerger08Inferred - Hoxa5 (100% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXB5 (100% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXB5 (100% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB5 (100% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB5 (100% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB5 (100% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB5 (100% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxb5 (100% AA Identity, Mus musculus)
B1HJASPARInferred - Scr (94% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Scr (94% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - Antp (92% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - HOXA7 (92% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA7 (92% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA7 (92% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxa7 (92% AA Identity, Mus musculus)
PBMBerger08Inferred - Hoxa7 (92% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXD4 (92% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXD4 (92% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD4 (92% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD4 (92% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD4 (92% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD4 (92% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Antp (92% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - HOXA7 (92% AA Identity, Homo sapiens)
MisciDMMPMMInferred - Antp (92% AA Identity, Drosophila melanogaster)
MiscHocoMocoInferred - HOXA7 (92% AA Identity, Homo sapiens)
MiscHocoMocoInferred - HOXD4 (92% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXA4 (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA4 (91% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxa4 (91% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXB4 (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB4 (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB4 (91% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxb4 (91% AA Identity, Mus musculus)
PBMBarrera2016Inferred - HOXC4 (91% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXC4 (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXC4 (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXC4 (91% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxc4 (91% AA Identity, Mus musculus)
PBMBerger08Inferred - Hoxc5 (91% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - HOXA4 (91% AA Identity, Homo sapiens)
MiscHOMERInferred - Hoxb4 (91% AA Identity, Mus musculus)
B1HJASPARInferred - Dfd (89% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Dfd (89% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Dfd (89% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - HOXA6 (89% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA6 (89% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA6 (89% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxa6 (89% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXB6 (89% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB6 (89% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB6 (89% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxb6 (89% AA Identity, Mus musculus)
PBMBarrera2016Inferred - HOXB7 (89% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXB7 (89% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXB7 (89% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB7 (89% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB7 (89% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB7 (89% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB7 (89% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxb7 (89% AA Identity, Mus musculus)
PBMBarrera2016Inferred - HOXC4 (89% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Dfd (89% AA Identity, Drosophila melanogaster)
MisciDMMPMMInferred - Dfd (89% AA Identity, Drosophila melanogaster)
MiscHocoMocoInferred - HOXB6 (89% AA Identity, Homo sapiens)
MiscHocoMocoInferred - HOXB7 (89% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - HOXB7 (87% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - HOXB7 (87% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxc6 (87% AA Identity, Mus musculus)
MiscHocoMocoInferred - HOXC6 (87% AA Identity, Homo sapiens)
B1HJASPARInferred - abd-A (85% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - abd-A (85% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - abd-A (85% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - ftz (85% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - ftz (85% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - abd-A (85% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - ftz (85% AA Identity, Drosophila melanogaster)
MisciDMMPMMInferred - abd-A (85% AA Identity, Drosophila melanogaster)
MisciDMMPMMInferred - ftz (85% AA Identity, Drosophila melanogaster)
PBMBusserDevelopment2012Inferred - Ubx (84% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - Ubx (84% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Ubx (84% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - Ubx (84% AA Identity, Drosophila melanogaster)
MisciDMMPMMInferred - Ubx (84% AA Identity, Drosophila melanogaster)
PBMBerger08Inferred - Hoxb3 (78% AA Identity, Mus musculus)
PBMBadis09Inferred - Hoxa3 (77% AA Identity, Mus musculus)
PBMBerger08Inferred - Hoxa3 (77% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXB8 (77% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB8 (77% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB8 (77% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxb8 (77% AA Identity, Mus musculus)
PBMZoo_01Inferred - SPU_026099 (77% AA Identity, Strongylocentrotus purpuratus)
TransfacTransfacLicense requiredInferred - HOXA3 (77% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - lin-39 (77% AA Identity, Caenorhabditis elegans)
MiscHocoMocoInferred - HOXB8 (77% AA Identity, Homo sapiens)
MiscHOMERInferred - lin-39 (77% AA Identity, Caenorhabditis elegans)
HT-SELEXYin2017Inferred - HOXC8 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXC8 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXC8 (75% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxc8 (75% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXD3 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD3 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD3 (75% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxd3 (75% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXD8 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD8 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD8 (75% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Q0N4M8_NEMVE (75% AA Identity, Nematostella vectensis)
TransfacTransfacLicense requiredInferred - HOXC8 (75% AA Identity, Homo sapiens)
MiscHocoMocoInferred - HOXC8 (75% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxd8 (73% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - PDX1 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - PDX1 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - PDX1 (73% AA Identity, Homo sapiens)
PBMBerger08Inferred - Pdx1 (73% AA Identity, Mus musculus)
SELEXJASPARInferred - PDX1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PDX1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PDX1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PDX1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PDX1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PDX1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PDX1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PDX1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PDX1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PDX1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PDX1 (73% AA Identity, Homo sapiens)
MiscHocoMocoInferred - PDX1 (73% AA Identity, Homo sapiens)
MiscHOMERInferred - Pdx1 (73% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXB9 (71% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXB9 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB9 (71% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxb9 (71% AA Identity, Mus musculus)
B1HJASPARInferred - pb (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - pb (71% AA Identity, Drosophila melanogaster)
PBMTF_EvolutionUnpublished DataInferred - Cbr-mab-5 (70% AA Identity, Caenorhabditis briggsae)
HT-SELEXYin2017Inferred - HOXA2 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXA2 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA2 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA2 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA2 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA2 (70% AA Identity, Homo sapiens)
PBMZoo_01Inferred - HOXA2 (70% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxa2 (70% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXB2 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB2 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB2 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXC9 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXC9 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXC9 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXC9 (70% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxc9 (70% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXD9 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXD9 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXD9 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXD9 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD9 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD9 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD9 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD9 (70% AA Identity, Homo sapiens)
B1HJASPARInferred - lab (70% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - lab (70% AA Identity, Drosophila melanogaster)
ChIP-seqJASPARInferred - Hoxc9 (70% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - HOXD9 (70% AA Identity, Homo sapiens)
MiscHOMERInferred - Hoxa2 (70% AA Identity, Mus musculus)
MiscHOMERInferred - Hoxc9 (70% AA Identity, Mus musculus)
MiscHocoMocoInferred - HOXD9 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GSX1 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GSX1 (68% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GSX2 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GSX2 (68% AA Identity, Homo sapiens)
PBMBerger08Inferred - Gsx2 (68% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXA9 (68% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXA9 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA9 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA9 (68% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxa9 (68% AA Identity, Mus musculus)
B1HJASPARInferred - ind (68% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - O76842_CUPSA (68% AA Identity, Cupiennius salei)
B1HJASPARInferred - zen (68% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - zen (68% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - HOXA9 (68% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - HOXA9 (68% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - HOXA9 (68% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - HOXA9 (68% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - Hoxa9 (68% AA Identity, Mus musculus)
MiscHocoMocoInferred - HOXA9 (68% AA Identity, Homo sapiens)
MiscHocoMocoInferred - HOXA9 (68% AA Identity, Homo sapiens)
MiscHOMERInferred - Hoxa9 (68% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXA1 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA1 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA1 (66% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxa1 (66% AA Identity, Mus musculus)
PBMZoo_01Inferred - Q7M3U4_ACRFO (66% AA Identity, Acropora formosa)
B1HJASPARInferred - zen2 (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - zen2 (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - zen2 (66% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - zen2 (66% AA Identity, Drosophila melanogaster)
MiscHocoMocoInferred - HOXA1 (66% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution