TF Info Page for USF2 (bHLH)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro Has a putative AT-hook

Description

Description: upstream transcription factor 2, c-fos interacting [Source:HGNC Symbol;Acc:HGNC:12594]
Entrez Summary NA
Ensembl ID: ENSG00000105698
External Link: CisBP
Interpro IPR011598; ;
Protein Domain: ENSP00000222305
Protein Domain: ENSP00000340633
Protein Domain: ENSP00000368429
Protein Domain: ENSP00000471511
Protein Domain: ENSP00000469585
Protein Domain: ENSP00000470081
Protein Domain: ENSP00000471775
Protein Domain: ENSP00000469364
Domain:
Protein: ENSP00000222305DBD: bHLHOther:
Protein: ENSP00000340633DBD: bHLHOther:
Protein: ENSP00000368429DBD: bHLHOther:
Protein: ENSP00000471511DBD: bHLHOther:
Protein: ENSP00000469585DBD: bHLHOther:
Protein: ENSP00000470081DBD: bHLHOther:
Protein: ENSP00000471775DBD: bHLHOther:
Protein: ENSP00000469364DBD: bHLHOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:15242350
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:1589769, PMID:8954795
GO:0003705
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
IMP - PMID:8576131
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqJASPARDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERInferred - Usf2 (98% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - USF1 (85% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - USF1 (85% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Usf1 (85% AA Identity, Mus musculus)
ChIP-seqENCODEInferred - USF1 (85% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - USF1 (85% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - USF1 (85% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - USF1 (85% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - USF1 (85% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - USF1 (85% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - USF1 (85% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - USF1 (85% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - USF1 (85% AA Identity, Homo sapiens)
MiscHocoMocoInferred - USF1 (85% AA Identity, Homo sapiens)
MiscHOMERInferred - USF1 (85% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Usf2 (53% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution