TF Info Page for ETV2 (Ets)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: ETS variant 2 [Source:HGNC Symbol;Acc:HGNC:3491]
Entrez Summary NA
Ensembl ID: ENSG00000105672
External Link: CisBP
Interpro IPR000418; ;
Protein Domain: ENSP00000368309
Protein Domain: ENSP00000384524
Protein Domain: ENSP00000468453
Protein Domain: ENSP00000368312
Protein Domain: ENSP00000385369
Protein Domain: ENSP00000475089
Domain:
Protein: ENSP00000368309DBD: ETSOther:
Protein: ENSP00000384524DBD: ETSOther:
Protein: ENSP00000468453DBD: ETSOther:
Protein: ENSP00000368312DBD: ETSOther:
Protein: ENSP00000385369DBD: ETSOther:
Protein: ENSP00000475089DBD: ETSOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
PBMWei10Inferred - Ets1 (60% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - pnt (60% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - ETS1B_CHICK (60% AA Identity, Gallus gallus)
HT-SELEXYin2017Inferred - FEV (54% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FEV (54% AA Identity, Homo sapiens)
MiscHocoMocoInferred - FEV (54% AA Identity, Homo sapiens)
HT-SELEXJolma2010Inferred - ERG (53% AA Identity, Homo sapiens)
HT-SELEXJolma2010Inferred - ERG (53% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (53% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (53% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (53% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (53% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (53% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (53% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (53% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (53% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - Ets65A (53% AA Identity, Drosophila melanogaster)
SMiLE-seqIsakova2017Inferred - FLI1 (53% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (53% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (53% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (53% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (53% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (53% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (53% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (53% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (53% AA Identity, Homo sapiens)
PBMWei10Inferred - Fli1 (53% AA Identity, Mus musculus)
SMiLE-seqIsakova2017Inferred - GABPA (53% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GABPA (53% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GABPA (53% AA Identity, Homo sapiens)
PBMBadis09Inferred - Gabpa (53% AA Identity, Mus musculus)
PBMWei10Inferred - Gabpa (53% AA Identity, Mus musculus)
SELEXJASPARInferred - ERG (53% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ERG (53% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ERG (53% AA Identity, Homo sapiens)
SELEXJASPARInferred - FLI1 (53% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FLI1 (53% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FLI1 (53% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (53% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (53% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (53% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (53% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (53% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (53% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (53% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (53% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (53% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (53% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (53% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - Gabpa (53% AA Identity, Mus musculus)
MiscHocoMocoInferred - ERG (53% AA Identity, Homo sapiens)
MiscHOMERInferred - ERG (53% AA Identity, Homo sapiens)
MiscHocoMocoInferred - FLI1 (53% AA Identity, Homo sapiens)
MiscHOMERInferred - Fli1 (53% AA Identity, Mus musculus)
MiscHocoMocoInferred - GABPA (53% AA Identity, Homo sapiens)
MiscHOMERInferred - GABPA (53% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution