TF Info Page for DBP (bZIP)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: D-box binding PAR bZIP transcription factor [Source:HGNC Symbol;Acc:HGNC:2697]
Entrez Summary The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]
Ensembl ID: ENSG00000105516
External Link: CisBP
Interpro IPR004827; ;
Protein Domain: ENSP00000222122
Protein Domain: ENSP00000469291
Protein Domain: ENSP00000471220
Protein Domain: ENSP00000469426
Domain:
Protein: ENSP00000222122DBD: bZIPOther:
Protein: ENSP00000469291DBD: bZIPOther:
Protein: ENSP00000471220DBD: bZIPOther:
Protein: ENSP00000469426DBD: bZIPOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:2331750
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:20093779
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMDREAM_contestInferred - Dbp (98% AA Identity, Mus musculus)
PBMZoo_01Inferred - Dbp (98% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - TEF (67% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TEF (67% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Tef (67% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - TEF (67% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TEF (67% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TEF (67% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TEF (67% AA Identity, Homo sapiens)
MiscHocoMocoInferred - TEF (67% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HLF (65% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HLF (65% AA Identity, Homo sapiens)
SELEXJASPARInferred - HLF (65% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - HLF (65% AA Identity, Homo sapiens)
MiscHocoMocoInferred - HLF (65% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - Pdp1 (60% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Pdp1 (60% AA Identity, Drosophila melanogaster)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution