get eID ENSG00000105392 else done selects

TF Info Page for CRX (Homeodomain)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: cone-rod homeobox [Source:HGNC Symbol;Acc:HGNC:2383]
Entrez Summary TBA
Ensembl ID: ENSG00000105392
External Link:
Interpro IPR001356; IPR009057; IPR013851; IPR017970;
Protein Domain:
Protein: ENSP00000221996DBD: HomeodomainOther: TF_Otx
Protein: ENSP00000478106DBD: HomeodomainOther:
Protein: ENSP00000445565DBD: HomeodomainOther: TF_Otx
Protein: ENSP00000457808DBD: HomeodomainOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:15001570 16332268
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources. 		a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:10625658
GO:0003700
sequence-specific DNA binding transcription factor activity
ISS - GO_REF:0000024
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF 		1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
PBMBarrera2016Direct
PBMBarrera2016Direct
PBMBarrera2016Direct
PBMBarrera2016Direct
PBMBarrera2016Direct
PBMBarrera2016Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMBerger08Inferred - Crx (100% AA Identity, Mus musculus)
ChIP-seqJASPARInferred - Crx (100% AA Identity, Mus musculus)
MiscHOMERInferred - Crx (100% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - OTX1 (89% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - OTX1 (89% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OTX1 (89% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OTX1 (89% AA Identity, Homo sapiens)
PBMBerger08Inferred - Otx1 (89% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - OTX1 (89% AA Identity, Homo sapiens)
MiscHocoMocoInferred - OTX1 (89% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - OTX2 (87% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OTX2 (87% AA Identity, Homo sapiens)
PBMBerger08Inferred - Otx2 (87% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - OTX2 (87% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - OTX2 (87% AA Identity, Homo sapiens)
MiscHocoMocoInferred - OTX2 (87% AA Identity, Homo sapiens)
MiscHOMERInferred - Otx2 (87% AA Identity, Mus musculus)
B1HJASPARInferred - oc (85% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - oc (85% AA Identity, Drosophila melanogaster)
MisciDMMPMMInferred - oc (85% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - CG11294 (73% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG11294 (73% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG11294 (73% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - DRGX (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DRGX (71% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Drgx (71% AA Identity, Rattus norvegicus)
HT-SELEXNitta2015Inferred - CG2808 (70% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - PHOX2A (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - PHOX2A (70% AA Identity, Homo sapiens)
PBMBerger08Inferred - Phox2a (70% AA Identity, Mus musculus)
PBMBarrera2016Inferred - PHOX2B (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - PHOX2B (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - PHOX2B (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - PHOX2B (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - PHOX2B (70% AA Identity, Homo sapiens)
PBMBerger08Inferred - Phox2b (70% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - RAX (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - RAX (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - RAX (70% AA Identity, Homo sapiens)
PBMBerger08Inferred - Rax (70% AA Identity, Mus musculus)
B1HJASPARInferred - Rx (70% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Rx (70% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Rx (70% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - Rax (70% AA Identity, Rattus norvegicus)
MiscHOMERInferred - Phox2a (70% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ALX1 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX1 (68% AA Identity, Homo sapiens)
PBMBerger08Inferred - Alx1 (68% AA Identity, Mus musculus)
PBMBerger08Inferred - Alx1 (68% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ALX3 (68% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ALX3 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX3 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX3 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX3 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX3 (68% AA Identity, Homo sapiens)
PBMBerger08Inferred - Alx3 (68% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ALX4 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX4 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX4 (68% AA Identity, Homo sapiens)
PBMBerger08Inferred - Alx4 (68% AA Identity, Mus musculus)
PBMCEPDInferred - ceh-37 (68% AA Identity, Caenorhabditis elegans)
PBMBarrera2016Inferred - PHOX2B (68% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ALX1 (68% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ALX4 (68% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ALX1 (68% AA Identity, Homo sapiens)
B1HJASPARInferred - al (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - al (66% AA Identity, Drosophila melanogaster)
PBMBarrera2016Inferred - ARX (66% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ARX (66% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ARX (66% AA Identity, Homo sapiens)
PBMBerger08Inferred - Arx (66% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - DMBX1 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DMBX1 (66% AA Identity, Homo sapiens)
PBMBerger08Inferred - Dmbx1 (66% AA Identity, Mus musculus)
SMiLE-seqIsakova2017Inferred - Gsc (66% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - Gsc (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Gsc (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Gsc (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Gsc (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Gsc (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Gsc (66% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - Gsc (66% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - repo (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - repo (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - repo (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - repo (66% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - Arx (66% AA Identity, Rattus norvegicus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution