(PMID: 26683827) uses SELEX to show binding to G/C rich DNA, and confirms association with rDNA promoters. Also claims it has a C2H2 domain. Interpro says it has a C2H2 AKAP95-type 1 and a C2H2 AKAP95-type 2 domain. SMART does identify a single C2H2 domain.
Description
Description:
A-kinase anchoring protein 8 [Source:HGNC Symbol;Acc:HGNC:378]
Entrez Summary
This gene encodes a member of the A-kinase anchor protein family.
A-kinase anchor proteins are scaffold proteins that contain a binding domain
for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other
signaling molecules to specific subcellular locations. This gene encodes a
nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA
and may play a role in chromosome condensation during mitosis by targeting
PKA and the condensin complex to chromatin. A pseudogene of this gene is
located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
x
CisBP considers it as a TF?
No
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
5a, one of the source datasets predicts is as a TF