Conclusion
Assessment
Binding Mode
Motif Status
Notes
Comments
Likely to be sequence specific TF
1 Monomer or homomultimer
No motif
Recognizes the PSE-element, which is located in the core promoters of snRNA genes, and helps to recruit TBP (PMID: 8633057)
Description
Description:
small nuclear RNA activating complex polypeptide 2 [Source:HGNC Symbol;Acc:HGNC:11135]
Entrez Summary
TBA
Ensembl ID:
ENSG00000104976
External Link:
Interpro
IPR021281 ;
Protein Domain:
Protein: ENSP00000221573DBD: OtherOther: SnAPC_2_likeProtein: ENSP00000471962DBD: OtherOther: SnAPC_2_likeProtein: ENSP00000469475DBD: OtherOther: SnAPC_2_like
Previous Annotations
Source
Annotation
TF-CAT classification
No PMIDS:
Vaquerizas 2009 TF classification
"a " Has direct evidence of TF function;
"b " Has evidence for an orthologous TF;
"c " contains likely DBDs, but has no functional evidence;
"x " is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other " category contains proteins without clear DBDs they curated from external sources.
No
CisBP considers it as a TF?
No
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:7715707, PMID:8524284
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
5a, one of the source datasets predicts is as a TF
TF has conditional DNA-binding requirements
DNA-Binding
Published Motif Data
Structure
Experimental History
{"regions": [{"startStyle": "straight", "end": 331, "endStyle": "straight", "aliStart": 1, "text": "SnAPC_2_like", "colour": "#9999ff", "aliEnd": 330, "start": 1, "href": "http://pfam.xfam.org/family/PF11035.6", "type": "pfama", "display": "true", "metadata": {"end": 331, "description": "This family of proteins is snRNA-activating protein complex subunit 2 (SnAPC subunit 2). SnAPC complex allows the transcription of human small nuclear RNA genes to occur by recognition of the proximal sequence element, the TATA box [1]. The family functions both to specifically recognise the proximal sequence element present in the core promoters of human snRNA genes and to stimulate TBP recognition of the neighbouring TATA box present in human U6 snRNA promoters [2,3].", "database": "PfamA", "aliStart": 1, "scoreName": "E-value", "accession": "PF11035.6", "start": 1, "score": 2.9999999999999992e-145, "identifier": "Small nuclear RNA activating complex subunit 2, SNAP190 Myb", "type": "DBD", "aliEnd": 330}}], "length": 335}
{"regions": [{"startStyle": "jagged", "end": 94, "endStyle": "straight", "aliStart": 1, "text": "SnAPC_2_like", "colour": "#9999ff", "aliEnd": 93, "start": 1, "href": "http://pfam.xfam.org/family/PF11035.6", "type": "pfama", "display": "true", "metadata": {"end": 94, "description": "This family of proteins is snRNA-activating protein complex subunit 2 (SnAPC subunit 2). SnAPC complex allows the transcription of human small nuclear RNA genes to occur by recognition of the proximal sequence element, the TATA box [1]. The family functions both to specifically recognise the proximal sequence element present in the core promoters of human snRNA genes and to stimulate TBP recognition of the neighbouring TATA box present in human U6 snRNA promoters [2,3].", "database": "PfamA", "aliStart": 1, "scoreName": "E-value", "accession": "PF11035.6", "start": 1, "score": 1.3e-29, "identifier": "Small nuclear RNA activating complex subunit 2, SNAP190 Myb", "type": "DBD", "aliEnd": 93}}], "length": 98}
{"regions": [{"startStyle": "straight", "end": 225, "endStyle": "jagged", "aliStart": 2, "text": "SnAPC_2_like", "colour": "#9999ff", "aliEnd": 222, "start": 1, "href": "http://pfam.xfam.org/family/PF11035.6", "type": "pfama", "display": "true", "metadata": {"end": 225, "description": "This family of proteins is snRNA-activating protein complex subunit 2 (SnAPC subunit 2). SnAPC complex allows the transcription of human small nuclear RNA genes to occur by recognition of the proximal sequence element, the TATA box [1]. The family functions both to specifically recognise the proximal sequence element present in the core promoters of human snRNA genes and to stimulate TBP recognition of the neighbouring TATA box present in human U6 snRNA promoters [2,3].", "database": "PfamA", "aliStart": 2, "scoreName": "E-value", "accession": "PF11035.6", "start": 1, "score": 5.699999999999999e-96, "identifier": "Small nuclear RNA activating complex subunit 2, SNAP190 Myb", "type": "DBD", "aliEnd": 222}}], "length": 280}