TF Info Page for RELB (Rel)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 2 Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Likely an obligate heteromer (PMID: 22101729)

Description

Description: RELB proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9956]
Entrez Summary NA
Ensembl ID: ENSG00000104856
External Link: CisBP
Interpro IPR000451; IPR002909; IPR008967; IPR011539; IPR014756; IPR030492;
Protein Domain: ENSP00000221452
Protein Domain: ENSP00000468460
Protein Domain: ENSP00000423287
Protein Domain: ENSP00000485826
Domain:
Protein: ENSP00000221452DBD: RHDOther: RHD_dimer, RelB_leu_zip, RelB_transactiv
Protein: ENSP00000468460DBD: RHDOther: RelB_transactiv
Protein: ENSP00000423287DBD: RHDOther: RHD_dimer, RelB_leu_zip, RelB_transactiv
Protein: ENSP00000485826DBD: RHDOther: RHD_dimer, RelB_leu_zip, RelB_transactiv

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific
Transcription Factor Binding
tf co-factor binding_Co-activation_
PMIDS:8183565 8183565 9070378
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:8188306
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect

Structure

Structure PDB 2V2T

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution