The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	2 Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Likely an obligate heteromer (PMID: 22101729)

Description

Description:	RELB proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9956]
Entrez Summary	TBA
Ensembl ID:	ENSG00000104856
External Link:	T138169_1.02
Interpro	IPR000451; IPR002909; IPR008967; IPR011539; IPR014756; IPR030492;
Protein Domain:
Protein: ENSP00000221452	DBD: RHD	Other: RHD_dimer, RelB_leu_zip, RelB_transactiv
Protein: ENSP00000468460	DBD: RHD	Other: RelB_transactiv
Protein: ENSP00000423287	DBD: RHD	Other: RHD_dimer, RelB_leu_zip, RelB_transactiv
Protein: ENSP00000485826	DBD: RHD	Other: RHD_dimer, RelB_leu_zip, RelB_transactiv

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific Transcription Factor Binding tf co-factor binding_Co-activation_ PMIDS:8183565 8183565 9070378
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA - GO_REF:0000033 GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:8188306
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct

Structure

Structure	PDB	2V2T

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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{"regions": [{"startStyle": "curved", "end": 292, "endStyle": "curved", "aliStart": 124, "text": "RHD", "colour": "#2cb42c", "aliEnd": 292, "start": 124, "href": "http://pfam.xfam.org/family/PF00554.20", "type": "pfama", "display": "true", "metadata": {"end": 292, "description": "Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. ", "database": "PfamA", "aliStart": 124, "scoreName": "E-value", "accession": "PF00554.20", "start": 124, "score": 8.999999999999999e-64, "identifier": "Rel homology DNA-binding domain", "type": "DBD", "aliEnd": 292}}, {"startStyle": "straight", "end": 576, "endStyle": "straight", "aliStart": 400, "text": "RelB_transactiv", "colour": "#9999ff", "aliEnd": 576, "start": 400, "href": "http://pfam.xfam.org/family/PF16181.3", "type": "pfama", "display": "true", "metadata": {"end": 576, "description": "This domain is the transactivation domain of the transcription factor RelB [1].", "database": "PfamA", "aliStart": 400, "scoreName": "E-value", "accession": "PF16181.3", "start": 400, "score": 2.4999999999999998e-98, "identifier": "RelB transactivation domain", "type": "DBD", "aliEnd": 576}}, {"startStyle": "straight", "end": 101, "endStyle": "straight", "aliStart": 18, "text": "RelB_leu_zip", "colour": "#9999ff", "aliEnd": 99, "start": 18, "href": "http://pfam.xfam.org/family/PF16180.3", "type": "pfama", "display": "true", "metadata": {"end": 101, "description": "This domain is a leucine zipper found in RelB transcription factors [1].", "database": "PfamA", "aliStart": 18, "scoreName": "E-value", "accession": "PF16180.3", "start": 18, "score": 3.9e-41, "identifier": "RelB leucine zipper", "type": "DBD", "aliEnd": 99}}, {"startStyle": "straight", "end": 398, "endStyle": "straight", "aliStart": 301, "text": "RHD_dimer", "colour": "#9999ff", "aliEnd": 397, "start": 301, "href": "http://pfam.xfam.org/family/PF16179.3", "type": "pfama", "display": "true", "metadata": {"end": 398, "description": "The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (Pfam:PF00554) and a C-terminal dimerisation domain. This is the dimerisation domain [1].", "database": "PfamA", "aliStart": 301, "scoreName": "E-value", "accession": "PF16179.3", "start": 301, "score": 7.8e-38, "identifier": "Rel homology dimerisation domain", "type": "DBD", "aliEnd": 397}}], "length": 577}

TF Info Page for RELB (Rel)