TF Info Page for TRPS1 (GATA)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Description
| Description: | transcriptional repressor GATA binding 1 [Source:HGNC Symbol;Acc:HGNC:12340] | ||||||||||||||||||||||||
| Entrez Summary | This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008] | ||||||||||||||||||||||||
| Ensembl ID: | ENSG00000104447 | ||||||||||||||||||||||||
| External Link: | CisBP | ||||||||||||||||||||||||
| Interpro | IPR000679; IPR007087; IPR015880; ; | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000220888 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000379065 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000429174 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000405028 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000428121 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000428680 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000379063 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000430383 | ||||||||||||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene Candidate_DNA-Binding sequence-specific_Other_ PMIDS:10615131 11112658 12761050 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IBA - GO_REF:0000033 GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:10615131 |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
2a1, Lower confidence direct evidence |
| TF has conditional DNA-binding requirements |