get eID ENSG00000104447 else done selects

TF Info Page for TRPS1 (GATA)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain

Description

Description: transcriptional repressor GATA binding 1 [Source:HGNC Symbol;Acc:HGNC:12340]
Entrez Summary TBA
Ensembl ID: ENSG00000104447
External Link: T084676_1.02
Interpro IPR000679; IPR007087; IPR015880; ;
Protein Domain:
Protein: ENSP00000220888DBD: GATAOther: zf-H2C2_5
Protein: ENSP00000379065DBD: GATAOther: zf-H2C2_5
Protein: ENSP00000429174DBD: GATAOther: Actin_micro, zf-H2C2_5
Protein: ENSP00000405028DBD: GATAOther:
Protein: ENSP00000428121DBD: GATAOther:
Protein: ENSP00000428680DBD: GATAOther: zf-H2C2_5
Protein: ENSP00000379063DBD: GATAOther:
Protein: ENSP00000430383DBD: GATAOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate_DNA-Binding
sequence-specific_Other_
PMIDS:10615131 11112658 12761050
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources. 		a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001228
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IBA - GO_REF:0000033
GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:10615131
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF 		2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution