TF Info Page for TRPS1 (GATA)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain


Description: transcriptional repressor GATA binding 1 [Source:HGNC Symbol;Acc:HGNC:12340]
Entrez Summary This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000104447
External Link: CisBP
Interpro IPR000679; IPR007087; IPR015880; ;
Protein Domain: ENSP00000220888
Protein Domain: ENSP00000379065
Protein Domain: ENSP00000429174
Protein Domain: ENSP00000405028
Protein Domain: ENSP00000428121
Protein Domain: ENSP00000428680
Protein Domain: ENSP00000379063
Protein Domain: ENSP00000430383
Protein: ENSP00000220888DBD: GATAOther: zf-H2C2_5
Protein: ENSP00000379065DBD: GATAOther: zf-H2C2_5
Protein: ENSP00000429174DBD: GATAOther: Actin_micro, zf-H2C2_5
Protein: ENSP00000405028DBD: GATAOther:
Protein: ENSP00000428121DBD: GATAOther:
Protein: ENSP00000428680DBD: GATAOther: zf-H2C2_5
Protein: ENSP00000379063DBD: GATAOther:
Protein: ENSP00000430383DBD: GATAOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate_DNA-Binding
PMIDS:10615131 11112658 12761050
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001228
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IBA - GO_REF:0000033
sequence-specific DNA binding transcription factor activity
TAS - PMID:10615131
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution