TF Info Page for SALL1 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Inferred motif 1 Monomer or homomultimer In vivo/Misc source

Description

Description: spalt like transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10524]
Entrez Summary The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000103449
External Link: CisBP
Interpro IPR007087; IPR015880;
Protein Domain: ENSP00000251020
Protein Domain: ENSP00000455582
Protein Domain: ENSP00000407914
Protein Domain: ENSP00000456777
Domain:
Protein: ENSP00000251020DBD: C2H2 ZF Containing ProteinsOther: IZUMO, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-met
Protein: ENSP00000455582DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000407914DBD: C2H2 ZF Containing ProteinsOther: IZUMO, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-met
Protein: ENSP00000456777DBD: C2H2 ZF Containing ProteinsOther: IZUMO, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-met

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_Transcription Regulatory Activity
heterochromatin interaction/binding_Other
TF PPI_
PMIDS:11836251
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IBA - GO_REF:0000033 | NAS - PMID:9425907
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
2a2, orthologous lower confidence evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredInferred - Sall1 (100% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Sall1 (100% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Sall1 (100% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution