TF Info Page for ZNF821 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: zinc finger protein 821 [Source:HGNC Symbol;Acc:HGNC:28043]
Entrez Summary This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Ensembl ID: ENSG00000102984
External Link: CisBP
Interpro IPR007087; IPR015880;
Protein Domain: ENSP00000313822
Protein Domain: ENSP00000405908
Protein Domain: ENSP00000458112
Protein Domain: ENSP00000456193
Protein Domain: ENSP00000455648
Protein Domain: ENSP00000481362
Domain:
Protein: ENSP00000313822DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_11, zf-C2H2_6, zf-met
Protein: ENSP00000405908DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_11, zf-C2H2_6, zf-met
Protein: ENSP00000458112DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_11, zf-met
Protein: ENSP00000456193DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_11, zf-met
Protein: ENSP00000455648DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_11, zf-C2H2_6, zf-met
Protein: ENSP00000481362DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
c
CisBP considers it as a TF? Yes
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution