TF Info Page for CENPT (Unknown)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Likely to be sequence specific TF | 3 Low specificity DNA-binding protein | No motif | Contains an archaeal histone-like fold (CBF_NFY). but at best would have low sequence specificity. Known role in centromere assembly and lack of known sequence specificity suggest that it is unlikely to be a sequence specific TF. |
Description
| Description: | centromere protein T [Source:HGNC Symbol;Acc:HGNC:25787] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000102901 | |
| External Link: | ||
| Interpro | IPR009072; ; | |
| Protein Domain: | ||
| Protein: ENSP00000400140 | DBD: Other | Other: Bromo_TP, CBFD_NFYB_HMF, CENP-S, CENP-T_C, CENP-T_ |
| Protein: ENSP00000457810 | DBD: Other | Other: Bromo_TP, CBFD_NFYB_HMF, CENP-S, CENP-T_C, CENP-T_ |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
No PMIDS: |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
c |
| CisBP considers it as a TF? | No |
| TFclass considers it as a TF? | No |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info | |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
5a, one of the source datasets predicts is as a TF |
| TF has conditional DNA-binding requirements |