TF Info Page for TSC22D1 (Unknown)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Likely to be sequence specific TF | 1 Monomer or homomultimer | No motif | TSC22D1 appears to homo- and heterodimerize with other TFs to affect transcription (PMID: 10488076). In vitro, it has been shown to bind GC-rich DNA sequences (PMID: 9022669) |
Description
| Description: | TSC22 domain family member 1 [Source:HGNC Symbol;Acc:HGNC:16826] | |||||||||||||||
| Entrez Summary | This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] | |||||||||||||||
| Ensembl ID: | ENSG00000102804 | |||||||||||||||
| External Link: | CisBP | |||||||||||||||
| Interpro | IPR000580; ; | |||||||||||||||
| Protein Domain: | ENSP00000261489 | |||||||||||||||
| Protein Domain: | ENSP00000397435 | |||||||||||||||
| Protein Domain: | ENSP00000437414 | |||||||||||||||
| Protein Domain: | ENSP00000481585 | |||||||||||||||
| Protein Domain: | ENSP00000483407 | |||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene Candidate_Transcription Factor Binding tf co-factor binding_Transactivation_ PMIDS:10488076 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | No |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0003700 sequence-specific DNA binding transcription factor activity IBA - GO_REF:0000033 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
4a, two or more datasets predict it as a TF |
| TF has conditional DNA-binding requirements |