Conclusion
Assessment
Binding Mode
Motif Status
Notes
Comments
Known motif
1 Monomer or homomultimer
High-throughput in vitro
Description
Description:
E74 like ETS transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:3319]
Entrez Summary
#!usr/local/bin/perl
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The protein encoded by this gene is a transcriptional activator
that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes.
The encoded protein is involved in natural killer cell development and
function, innate immunity, and induction of cell cycle arrest in naive CD8+
cells. Two transcript variants encoding the same protein have been found for
this gene.[provided by RefSeq, Jan 2010]
Ensembl ID:
ENSG00000102034
External Link:
CisBP
Interpro
IPR000418 ; IPR022084 ;
Protein Domain:
ENSP00000311280
Protein Domain:
ENSP00000338608
Protein Domain:
ENSP00000407572
Protein Domain:
ENSP00000478297
Domain:
Protein: ENSP00000311280DBD: ETSOther: Elf-1_NProtein: ENSP00000338608DBD: ETSOther: Elf-1_NProtein: ENSP00000407572DBD: ETSOther: Elf-1_NProtein: ENSP00000478297DBD: ETSOther: Elf-1_N
Previous Annotations
Source
Annotation
TF-CAT classification
TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:8895518
Vaquerizas 2009 TF classification
"a " Has direct evidence of TF function;
"b " Has evidence for an orthologous TF;
"c " contains likely DBDs, but has no functional evidence;
"x " is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other " category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:14625302
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements
DNA-Binding
Published Motif Data
Structure
Experimental History
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