Vasoactive intestinal peptide is a neuroprotective factor that has
a stimulatory effect on the growth of some tumor cells and an inhibitory
effect on others. This gene encodes a protein that is upregulated by
vasoactive intestinal peptide and may be involved in its stimulatory effect
on certain tumor cells. The encoded protein contains one homeobox and nine
zinc finger domains, suggesting that it functions as a transcription factor.
This gene is also upregulated in normal proliferative tissues. Finally, the
encoded protein may increase the viability of certain cell types through
modulation of p53 activity. Alternatively spliced transcript variants
encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
3a, decent circumstantial evidence for its role as