TF Info Page for NFATC2 (Rel)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: nuclear factor of activated T-cells 2 [Source:HGNC Symbol;Acc:HGNC:7776]
Entrez Summary This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]
Ensembl ID: ENSG00000101096
External Link: CisBP
Interpro IPR002909; IPR008366; IPR008967; IPR011539; IPR014756; ;
Protein Domain: ENSP00000360619
Protein Domain: ENSP00000379330
Protein Domain: ENSP00000396471
Protein Domain: ENSP00000477342
Protein Domain: ENSP00000477370
Protein Domain: ENSP00000477142
Domain:
Protein: ENSP00000360619DBD: RHDOther: RHD_dimer, TIG
Protein: ENSP00000379330DBD: RHDOther: RHD_dimer, TIG
Protein: ENSP00000396471DBD: RHDOther: RHD_dimer, TIG
Protein: ENSP00000477342DBD: RHDOther: RHD_dimer, TIG
Protein: ENSP00000477370DBD: RHDOther: RHD_dimer, TIG
Protein: ENSP00000477142DBD: RHDOther: RHD_dimer, TIG

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:10692237 11786533 8313907 8397339 15684054 12453415 14688323
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
GO:0001078
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:8668213
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
PBMZoo_01Direct
COMPILEDJASPARDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMZoo_01Inferred - NFATC1 (84% AA Identity, Meleagris gallopavo)
HT-SELEXJolma2010Inferred - NFATC1 (83% AA Identity, Homo sapiens)
HT-SELEXJolma2010Inferred - NFATC1 (83% AA Identity, Homo sapiens)
HT-SELEXJolma2010Inferred - NFATC1 (83% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NFATC1 (83% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NFATC1 (83% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NFATC1 (83% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NFATC1 (83% AA Identity, Homo sapiens)
PBMZoo_01Inferred - NFATC1 (83% AA Identity, Monodelphis domestica)
PBMZoo_01Inferred - nfatc1 (83% AA Identity, Xenopus tropicalis)
TransfacTransfacLicense requiredInferred - NFATC1 (83% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NFATC1 (83% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NFATC1 (83% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NFATC1 (83% AA Identity, Homo sapiens)
MiscHOMERInferred - NFATC1 (83% AA Identity, Homo sapiens)
PBMZoo_01Inferred - NFATC2 (78% AA Identity, Tetraodon nigroviridis)
HT-SELEXYin2017Inferred - NFATC3 (78% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NFATC3 (78% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NFATC3 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NFATC3 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NFATC3 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NFATC3 (78% AA Identity, Homo sapiens)
PBMZoo_01Inferred - NFATC3 (78% AA Identity, Homo sapiens)
PBMTF_EvolutionUnpublished DataInferred - NFATC4 (78% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NFATC4 (78% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NFATC4 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NFATC4 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NFATC4 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NFATC3 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NFATC4 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NFATC4 (78% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NFATC3 (78% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NFATC4 (78% AA Identity, Homo sapiens)

Structure

Structure PDB 1A02

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution