TF Info Page for MYBL2 (Myb/SANT)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro Contains 3 Myb DBDs

Description

Description: MYB proto-oncogene like 2 [Source:HGNC Symbol;Acc:HGNC:7548]
Entrez Summary The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Ensembl ID: ENSG00000101057
External Link: CisBP
Interpro IPR001005; IPR009057; IPR015395; IPR017877; IPR017930; ;
Protein Domain: ENSP00000217026
Protein Domain: ENSP00000380072
Domain:
Protein: ENSP00000217026DBD: Myb, Myb-Like, and SANT Domain Containing GenesOther: Cmyb_C
Protein: ENSP00000380072DBD: Myb, Myb-Like, and SANT Domain Containing GenesOther: Cmyb_C

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:1861984 8631934 11997503
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:10770937
GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:10770937
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
MiscHocoMocoDirect
MiscHOMERDirect
TransfacTransfacLicense requiredInferred - MYB_AVIMB (79% AA Identity, Avian myeloblastosis virus)
TransfacTransfacLicense requiredInferred - MYB_AVIMB (79% AA Identity, Avian myeloblastosis virus)
PBMDREAM_contestInferred - Mybl2 (76% AA Identity, Mus musculus)
PBMBadis09Inferred - Myb (75% AA Identity, Mus musculus)
PBMBadis09Inferred - Mybl1 (75% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - MYB (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MYB (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MYB (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MYB (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MYB (75% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - Myb (75% AA Identity, Mus musculus)
MiscHocoMocoInferred - MYB (75% AA Identity, Homo sapiens)
MiscHOMERInferred - Myb (75% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution