The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:

nuclear factor of activated T-cells 4 [Source:HGNC Symbol;Acc:HGNC:7778]

Entrez Summary

This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Ensembl ID:

ENSG00000100968

External Link:

CisBP

Interpro

IPR002909; IPR008366; IPR008967; IPR011539; IPR014756; ;

Protein Domain:

ENSP00000250373

Protein Domain:

ENSP00000388910

Protein Domain:

ENSP00000396788

Protein Domain:

ENSP00000388668

Protein Domain:

ENSP00000439350

Protein Domain:

ENSP00000451502

Protein Domain:

ENSP00000450590

Protein Domain:

ENSP00000451151

Protein Domain:

ENSP00000450469

Protein Domain:

ENSP00000450810

Protein Domain:

ENSP00000452039

Protein Domain:

ENSP00000450733

Protein Domain:

ENSP00000450644

Protein Domain:

ENSP00000451395

Protein Domain:

ENSP00000451801

Protein Domain:

ENSP00000450686

Protein Domain:

ENSP00000451224

Protein Domain:

ENSP00000451590

Protein Domain:

ENSP00000451454

Protein Domain:

ENSP00000452270

Protein Domain:

ENSP00000451183

Protein Domain:

ENSP00000451284

Protein Domain:

ENSP00000452349

Protein Domain:

ENSP00000451496

Domain:

Protein: ENSP00000250373	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000388910	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000396788	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000388668	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000439350	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000451502	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000450590	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000451151	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000450469	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000450810	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000452039	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000450733	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000450644	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000451395	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000451801	DBD: RHD	Other:
Protein: ENSP00000450686	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000451224	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000451590	DBD: RHD	Other:
Protein: ENSP00000451454	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000452270	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000451183	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000451284	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000452349	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000451496	DBD: RHD	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_Transcription Factor Binding tf co-factor binding_Co-activation_ PMIDS:11514544 11997522 16644691 17430895 16644691 12796475 16644691
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IEA - GO_REF:0000019 GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IGI - PMID:23543060
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
PBM	TF_Evolution	Unpublished Data	Direct
HT-SELEX	Yin2017		Direct
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
HT-SELEX	Yin2017		Inferred - NFATC3 (80% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - NFATC3 (80% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - NFATC3 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - NFATC3 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - NFATC3 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - NFATC3 (80% AA Identity, Homo sapiens)
PBM	Zoo_01		Inferred - NFATC3 (80% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - NFATC3 (80% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - NFATC3 (80% AA Identity, Homo sapiens)
PBM	Zoo_01		Inferred - NFATC1 (79% AA Identity, Monodelphis domestica)
HT-SELEX	Jolma2010		Inferred - NFATC1 (78% AA Identity, Homo sapiens)
HT-SELEX	Jolma2010		Inferred - NFATC1 (78% AA Identity, Homo sapiens)
HT-SELEX	Jolma2010		Inferred - NFATC1 (78% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - NFATC1 (78% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - NFATC1 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - NFATC1 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - NFATC1 (78% AA Identity, Homo sapiens)
PBM	Zoo_01		Inferred - NFATC1 (78% AA Identity, Meleagris gallopavo)
HT-SELEX	Yin2017		Inferred - NFATC2 (78% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - NFATC2 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - NFATC2 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - NFATC2 (78% AA Identity, Homo sapiens)
PBM	Zoo_01		Inferred - NFATC2 (78% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - NFATC1 (78% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - NFATC1 (78% AA Identity, Homo sapiens)
COMPILED	JASPAR		Inferred - NFATC2 (78% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - NFATC2 (78% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - NFATC2 (78% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - NFATC2 (78% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - NFATC1 (78% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - NFATC1 (78% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - NFATC1 (78% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - NFATC2 (78% AA Identity, Homo sapiens)
PBM	Zoo_01		Inferred - nfatc1 (77% AA Identity, Xenopus tropicalis)
PBM	Zoo_01		Inferred - NFATC2 (72% AA Identity, Tetraodon nigroviridis)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for NFATC4 (Rel)

Conclusion

Description

Previous Annotations

DNA-Binding

Published Motif Data

Structure

Experimental History

External Contribution