TF Info Page for YY1 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: YY1 transcription factor [Source:HGNC Symbol;Acc:HGNC:12856]
Entrez Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Ensembl ID: ENSG00000100811
External Link: CisBP
Interpro IPR007087; IPR015880; IPR017114; ;
Protein Domain: ENSP00000262238
Protein Domain: ENSP00000452140
Protein Domain: ENSP00000451329
Protein Domain: ENSP00000452225
Domain:
Protein: ENSP00000262238DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000452140DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000451329DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000452225DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:12584314 7501456 9141463 10452940 7565750 15316102 1655281 1720509
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001078
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
ISS - GO_REF:0000024
GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:1946405
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
SMiLE-seqIsakova2017Direct
HT-SELEXJolma2013Direct
RCADESchmitges2016Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqJASPARDirect
ChIP-seqNajafabadi2015Direct
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
TransfacTransfacLicense requiredInferred - TYY2_RAT (89% AA Identity, Rattus norvegicus)
HT-SELEXYin2017Inferred - YY2 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - YY2 (81% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ZFP42 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ZFP42 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ZFP42 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Zfp42 (70% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Zfp42 (70% AA Identity, Mus musculus)

Structure

Structure PDB 1UBD

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution