TF Info Page for HIF1A (bHLH)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 2 Obligate heteromer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain | Binds as obligate heteromer with ARNT (PMID: 9027737). |
Description
| Description: | hypoxia inducible factor 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:4910] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000100644 | |
| External Link: | ||
| Interpro | IPR000014; IPR001321; IPR001610; IPR011598; IPR013767; IPR014887; IPR021537; ; | |
| Protein Domain: | ||
| Protein: ENSP00000323326 | DBD: bHLH | Other: HIF-1, PAS, PAS_11, PAS_3, PAS_4, PAS_9 |
| Protein: ENSP00000338018 | DBD: bHLH | Other: HIF-1, HIF-1a_CTAD, PAS, PAS_11, PAS_3, PAS_4, PAS |
| Protein: ENSP00000378446 | DBD: bHLH | Other: HIF-1, HIF-1a_CTAD, PAS, PAS_11, PAS_3, PAS_4, PAS |
| Protein: ENSP00000437955 | DBD: bHLH | Other: HIF-1, HIF-1a_CTAD, PAS, PAS_11, PAS_3, PAS_4, PAS |
| Protein: ENSP00000451696 | DBD: bHLH | Other: HIF-1, HIF-1a_CTAD, PAS, PAS_11, PAS_3, PAS_4, PAS |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_Transactivation_ PMIDS:12133832 15111179 15906272 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IEA - GO_REF:0000019 GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IMP - PMID:24983504 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:11782478, PMID:18658046 | TAS - PMID:15 GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA - PMID:7539918, PMID:8387214, PMID:8756616, PM |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements | Obligate_Multimer |