TF Info Page for HIF1A (bHLH)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 2 Obligate heteromer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain | Binds as obligate heteromer with ARNT (PMID: 9027737). |
Description
| Description: | hypoxia inducible factor 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:4910] | |||||||||||||||
| Entrez Summary | This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] | |||||||||||||||
| Ensembl ID: | ENSG00000100644 | |||||||||||||||
| External Link: | CisBP | |||||||||||||||
| Interpro | IPR000014; IPR001321; IPR001610; IPR011598; IPR013767; IPR014887; IPR021537; ; | |||||||||||||||
| Protein Domain: | ENSP00000323326 | |||||||||||||||
| Protein Domain: | ENSP00000338018 | |||||||||||||||
| Protein Domain: | ENSP00000378446 | |||||||||||||||
| Protein Domain: | ENSP00000437955 | |||||||||||||||
| Protein Domain: | ENSP00000451696 | |||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_Transactivation_ PMIDS:12133832 15111179 15906272 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IEA - GO_REF:0000019 GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IMP - PMID:24983504 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:11782478, PMID:18658046 | TAS - PMID:15 GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA - PMID:7539918, PMID:8387214, PMID:8756616, PM |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements | Obligate_Multimer |