X-box binding protein 1 [Source:HGNC Symbol;Acc:HGNC:12801]
Entrez Summary
#!usr/local/bin/perl
?>
This gene encodes a transcription factor that regulates MHC class
II genes by binding to a promoter element referred to as an X box. This gene
product is a bZIP protein, which was also identified as a cellular
transcription factor that binds to an enhancer in the promoter of the T cell
leukemia virus type 1 promoter. It may increase expression of viral proteins
by acting as the DNA binding partner of a viral transactivator. It has been
found that upon accumulation of unfolded proteins in the endoplasmic
reticulum (ER), the mRNA of this gene is processed to an active form by an
unconventional splicing mechanism that is mediated by the endonuclease
inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the
spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the
functionally active transcription factor. The isoform encoded by the
unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function
as a negative feedback regulator of XBP1(S), which shuts off transcription of
target genes during the recovery phase of ER stress. A pseudogene of XBP1 has
been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IEA - GO_REF:0000019 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:1903538, PMID:8657566
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF