TF Info Page for FBXL19 (CxxC)


Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 1 Monomer or homomultimer No motif


Description: F-box and leucine rich repeat protein 19 [Source:HGNC Symbol;Acc:HGNC:25300]
Entrez Summary This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Ensembl ID: ENSG00000099364
External Link: CisBP
Interpro IPR001611; IPR001810; IPR001965; IPR002857; IPR006553; IPR011011; IPR019786; IPR019787;
Protein Domain: ENSP00000397913
Protein Domain: ENSP00000369666
Protein Domain: ENSP00000458033
Protein Domain: ENSP00000455529
Protein Domain: ENSP00000457199
Protein: ENSP00000397913DBD: CxxCOther: F-box, F-box-like, LRR_4, LRR_6, LRR_8, PHD, PHD_4
Protein: ENSP00000369666DBD: CxxCOther: F-box, F-box-like, LRR_4, LRR_6, LRR_8, PHD, PHD_4
Protein: ENSP00000458033DBD: CxxCOther: F-box, F-box-like, LRR_1, LRR_4, LRR_6, LRR_8
Protein: ENSP00000455529DBD: CxxCOther: F-box, F-box-like, LRR_4, LRR_6, LRR_8, PHD, PHD_4
Protein: ENSP00000457199DBD: CxxCOther:

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
5a, one of the source datasets predicts is as a TF
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution