The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:

cAMP responsive element modulator

Entrez Summary

Ensembl ID:

ENSG00000095794

External Link:

CisBP

Interpro

IPR001630; IPR003102; IPR004827; ;

Protein Domain:

ENSP00000341875

Protein Domain:

ENSP00000265372

Protein Domain:

ENSP00000345384

Protein Domain:

ENSP00000346804

Protein Domain:

ENSP00000363858

Protein Domain:

ENSP00000420681

Protein Domain:

ENSP00000417807

Protein Domain:

ENSP00000344365

Protein Domain:

ENSP00000349387

Protein Domain:

ENSP00000420437

Protein Domain:

ENSP00000418336

Protein Domain:

ENSP00000419018

Protein Domain:

ENSP00000417562

Protein Domain:

ENSP00000417460

Protein Domain:

ENSP00000419075

Protein Domain:

ENSP00000417327

Protein Domain:

ENSP00000403938

Protein Domain:

ENSP00000419810

Protein Domain:

ENSP00000473519

Protein Domain:

ENSP00000419924

Protein Domain:

ENSP00000417399

Domain:

Protein: ENSP00000341875	DBD: bZIP	Other: pKID
Protein: ENSP00000265372	DBD: bZIP	Other: pKID
Protein: ENSP00000345384	DBD: bZIP	Other: pKID
Protein: ENSP00000346804	DBD: bZIP	Other: pKID
Protein: ENSP00000363858	DBD: bZIP	Other: pKID
Protein: ENSP00000420681	DBD: bZIP	Other:
Protein: ENSP00000417807	DBD: bZIP	Other:
Protein: ENSP00000344365	DBD: bZIP	Other:
Protein: ENSP00000349387	DBD: bZIP	Other:
Protein: ENSP00000420437	DBD: bZIP	Other:
Protein: ENSP00000418336	DBD: bZIP	Other:
Protein: ENSP00000419018	DBD: bZIP	Other:
Protein: ENSP00000417562	DBD: bZIP	Other:
Protein: ENSP00000417460	DBD: bZIP	Other:
Protein: ENSP00000419075	DBD: bZIP	Other:
Protein: ENSP00000417327	DBD: bZIP	Other:
Protein: ENSP00000403938	DBD: bZIP	Other: pKID
Protein: ENSP00000419810	DBD: bZIP	Other:
Protein: ENSP00000473519	DBD: bZIP	Other:
Protein: ENSP00000419924	DBD: bZIP	Other: pKID
Protein: ENSP00000417399	DBD: bZIP	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info	GO:0003700 sequence-specific DNA binding transcription factor activity IEA - GO_REF:0000002
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
PBM	Zoo_01		Inferred - Crem (78% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
PBM	Mann2013		Inferred - Creb1 (75% AA Identity, Mus musculus)
PBM	Mann2013		Inferred - Creb1 (75% AA Identity, Mus musculus)
PBM	Zoo_01		Inferred - Creb1 (75% AA Identity, Mus musculus)
COMPILED	JASPAR		Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ATF1 (73% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ATF1 (73% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ATF1 (73% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ATF1 (73% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - ATF1 (73% AA Identity, Homo sapiens)
PBM	Badis09		Inferred - Atf1 (72% AA Identity, Mus musculus)
PBM	Zoo_01		Inferred - Atf1 (72% AA Identity, Mus musculus)
HT-SELEX	Nitta2015		Inferred - CrebB-17A (66% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - CrebB-17A (66% AA Identity, Drosophila melanogaster)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "curved", "end": 244, "endStyle": "curved", "aliStart": 184, "text": "bZIP", "colour": "#009900", "aliEnd": 240, "start": 184, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 244, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 184, "scoreName": "E-value", "accession": "PF00170.19", "start": 184, "score": 5.1e-21, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 240}}, {"startStyle": "jagged", "end": 238, "endStyle": "jagged", "aliStart": 188, "text": "MAF", "colour": "#FFD800", "aliEnd": 235, "start": 179, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 238, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 188, "scoreName": "E-value", "accession": "PF03131.15", "start": 179, "score": 0.0033, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 235}}, {"startStyle": "straight", "end": 52, "endStyle": "straight", "aliStart": 14, "text": "pKID", "colour": "#9999ff", "aliEnd": 52, "start": 10, "href": "http://pfam.xfam.org/family/PF02173.15", "type": "pfama", "display": "true", "metadata": {"end": 52, "description": "CBP and P300 bind to the pKID (phosphorylated kinase-inducible-domain) domain of CREB [1].", "database": "PfamA", "aliStart": 14, "scoreName": "E-value", "accession": "PF02173.15", "start": 10, "score": 1.1000000000000002e-19, "identifier": "pKID domain", "type": "DBD", "aliEnd": 52}}], "length": 246}

{"regions": [{"startStyle": "curved", "end": 299, "endStyle": "curved", "aliStart": 239, "text": "bZIP", "colour": "#009900", "aliEnd": 295, "start": 239, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 299, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 239, "scoreName": "E-value", "accession": "PF00170.19", "start": 239, "score": 6.7000000000000005e-21, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 295}}, {"startStyle": "jagged", "end": 293, "endStyle": "jagged", "aliStart": 243, "text": "MAF", "colour": "#FFD800", "aliEnd": 290, "start": 234, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 293, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 243, "scoreName": "E-value", "accession": "PF03131.15", "start": 234, "score": 0.0034, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 290}}, {"startStyle": "straight", "end": 107, "endStyle": "straight", "aliStart": 69, "text": "pKID", "colour": "#9999ff", "aliEnd": 107, "start": 65, "href": "http://pfam.xfam.org/family/PF02173.15", "type": "pfama", "display": "true", "metadata": {"end": 107, "description": "CBP and P300 bind to the pKID (phosphorylated kinase-inducible-domain) domain of CREB [1].", "database": "PfamA", "aliStart": 69, "scoreName": "E-value", "accession": "PF02173.15", "start": 65, "score": 6.400000000000001e-20, "identifier": "pKID domain", "type": "DBD", "aliEnd": 107}}], "length": 301}

{"regions": [{"startStyle": "curved", "end": 220, "endStyle": "curved", "aliStart": 160, "text": "bZIP", "colour": "#009900", "aliEnd": 216, "start": 160, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 220, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 160, "scoreName": "E-value", "accession": "PF00170.19", "start": 160, "score": 4.0000000000000004e-21, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 216}}, {"startStyle": "jagged", "end": 214, "endStyle": "jagged", "aliStart": 164, "text": "MAF", "colour": "#FFD800", "aliEnd": 211, "start": 155, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 214, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 164, "scoreName": "E-value", "accession": "PF03131.15", "start": 155, "score": 0.0023, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 211}}, {"startStyle": "straight", "end": 91, "endStyle": "straight", "aliStart": 53, "text": "pKID", "colour": "#9999ff", "aliEnd": 91, "start": 49, "href": "http://pfam.xfam.org/family/PF02173.15", "type": "pfama", "display": "true", "metadata": {"end": 91, "description": "CBP and P300 bind to the pKID (phosphorylated kinase-inducible-domain) domain of CREB [1].", "database": "PfamA", "aliStart": 53, "scoreName": "E-value", "accession": "PF02173.15", "start": 49, "score": 9.7e-20, "identifier": "pKID domain", "type": "DBD", "aliEnd": 91}}], "length": 222}

{"regions": [{"startStyle": "curved", "end": 246, "endStyle": "jagged", "aliStart": 188, "text": "bZIP", "colour": "#009900", "aliEnd": 243, "start": 188, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 246, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 188, "scoreName": "E-value", "accession": "PF00170.19", "start": 188, "score": 2.1e-19, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 243}}, {"startStyle": "jagged", "end": 243, "endStyle": "jagged", "aliStart": 192, "text": "MAF", "colour": "#FFD800", "aliEnd": 240, "start": 183, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 243, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 192, "scoreName": "E-value", "accession": "PF03131.15", "start": 183, "score": 0.0087, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 240}}, {"startStyle": "straight", "end": 107, "endStyle": "straight", "aliStart": 69, "text": "pKID", "colour": "#9999ff", "aliEnd": 107, "start": 65, "href": "http://pfam.xfam.org/family/PF02173.15", "type": "pfama", "display": "true", "metadata": {"end": 107, "description": "CBP and P300 bind to the pKID (phosphorylated kinase-inducible-domain) domain of CREB [1].", "database": "PfamA", "aliStart": 69, "scoreName": "E-value", "accession": "PF02173.15", "start": 65, "score": 1.1999999999999999e-19, "identifier": "pKID domain", "type": "DBD", "aliEnd": 107}}], "length": 249}

{"regions": [{"startStyle": "curved", "end": 119, "endStyle": "jagged", "aliStart": 60, "text": "bZIP", "colour": "#009900", "aliEnd": 115, "start": 60, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 119, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 60, "scoreName": "E-value", "accession": "PF00170.19", "start": 60, "score": 3.8e-20, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 115}}, {"startStyle": "jagged", "end": 115, "endStyle": "jagged", "aliStart": 64, "text": "MAF", "colour": "#FFD800", "aliEnd": 112, "start": 54, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 115, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 64, "scoreName": "E-value", "accession": "PF03131.15", "start": 54, "score": 0.0017, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 112}}], "length": 121}

{"regions": [{"startStyle": "curved", "end": 120, "endStyle": "curved", "aliStart": 60, "text": "bZIP", "colour": "#009900", "aliEnd": 116, "start": 60, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 120, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 60, "scoreName": "E-value", "accession": "PF00170.19", "start": 60, "score": 1.5999999999999999e-21, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 116}}, {"startStyle": "jagged", "end": 114, "endStyle": "jagged", "aliStart": 64, "text": "MAF", "colour": "#FFD800", "aliEnd": 111, "start": 54, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 114, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 64, "scoreName": "E-value", "accession": "PF03131.15", "start": 54, "score": 0.00045, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 111}}], "length": 122}

{"regions": [{"startStyle": "curved", "end": 94, "endStyle": "jagged", "aliStart": 35, "text": "bZIP", "colour": "#009900", "aliEnd": 90, "start": 35, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 94, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 35, "scoreName": "E-value", "accession": "PF00170.19", "start": 35, "score": 2.2000000000000002e-20, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 90}}, {"startStyle": "jagged", "end": 90, "endStyle": "jagged", "aliStart": 39, "text": "MAF", "colour": "#FFD800", "aliEnd": 87, "start": 28, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 90, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 39, "scoreName": "E-value", "accession": "PF03131.15", "start": 28, "score": 0.00093, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 87}}], "length": 96}

{"regions": [{"startStyle": "curved", "end": 107, "endStyle": "jagged", "aliStart": 48, "text": "bZIP", "colour": "#009900", "aliEnd": 103, "start": 48, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 107, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 48, "scoreName": "E-value", "accession": "PF00170.19", "start": 48, "score": 2.9999999999999997e-20, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 103}}, {"startStyle": "jagged", "end": 103, "endStyle": "jagged", "aliStart": 52, "text": "MAF", "colour": "#FFD800", "aliEnd": 100, "start": 41, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 103, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 52, "scoreName": "E-value", "accession": "PF03131.15", "start": 41, "score": 0.0013, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 100}}], "length": 109}

{"regions": [{"startStyle": "curved", "end": 137, "endStyle": "curved", "aliStart": 77, "text": "bZIP", "colour": "#009900", "aliEnd": 133, "start": 77, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 137, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 77, "scoreName": "E-value", "accession": "PF00170.19", "start": 77, "score": 2.0999999999999997e-21, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 133}}, {"startStyle": "jagged", "end": 131, "endStyle": "jagged", "aliStart": 81, "text": "MAF", "colour": "#FFD800", "aliEnd": 128, "start": 71, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 131, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 81, "scoreName": "E-value", "accession": "PF03131.15", "start": 71, "score": 0.0006, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 128}}], "length": 139}

{"regions": [{"startStyle": "curved", "end": 95, "endStyle": "curved", "aliStart": 35, "text": "bZIP", "colour": "#009900", "aliEnd": 91, "start": 35, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 95, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 35, "scoreName": "E-value", "accession": "PF00170.19", "start": 35, "score": 8.9e-22, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 91}}, {"startStyle": "jagged", "end": 89, "endStyle": "jagged", "aliStart": 39, "text": "MAF", "colour": "#FFD800", "aliEnd": 86, "start": 28, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 89, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 39, "scoreName": "E-value", "accession": "PF03131.15", "start": 28, "score": 0.00026000000000000003, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 86}}], "length": 97}

{"regions": [{"startStyle": "curved", "end": 111, "endStyle": "jagged", "aliStart": 52, "text": "bZIP", "colour": "#009900", "aliEnd": 107, "start": 52, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 111, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 52, "scoreName": "E-value", "accession": "PF00170.19", "start": 52, "score": 2.9e-20, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 107}}, {"startStyle": "jagged", "end": 107, "endStyle": "jagged", "aliStart": 56, "text": "MAF", "colour": "#FFD800", "aliEnd": 104, "start": 45, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 107, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 56, "scoreName": "E-value", "accession": "PF03131.15", "start": 45, "score": 0.0012, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 104}}], "length": 113}

{"regions": [{"startStyle": "curved", "end": 108, "endStyle": "curved", "aliStart": 48, "text": "bZIP", "colour": "#009900", "aliEnd": 104, "start": 48, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 108, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 48, "scoreName": "E-value", "accession": "PF00170.19", "start": 48, "score": 1.2e-21, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 104}}, {"startStyle": "jagged", "end": 102, "endStyle": "jagged", "aliStart": 52, "text": "MAF", "colour": "#FFD800", "aliEnd": 99, "start": 41, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 102, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 52, "scoreName": "E-value", "accession": "PF03131.15", "start": 41, "score": 0.00035, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 99}}], "length": 110}

{"regions": [{"startStyle": "curved", "end": 101, "endStyle": "jagged", "aliStart": 42, "text": "bZIP", "colour": "#009900", "aliEnd": 97, "start": 42, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 101, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 42, "scoreName": "E-value", "accession": "PF00170.19", "start": 42, "score": 2.6000000000000002e-20, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 97}}, {"startStyle": "jagged", "end": 97, "endStyle": "jagged", "aliStart": 46, "text": "MAF", "colour": "#FFD800", "aliEnd": 94, "start": 35, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 97, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 46, "scoreName": "E-value", "accession": "PF03131.15", "start": 35, "score": 0.0011, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 94}}], "length": 103}

{"regions": [{"startStyle": "curved", "end": 112, "endStyle": "curved", "aliStart": 52, "text": "bZIP", "colour": "#009900", "aliEnd": 108, "start": 52, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 112, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 52, "scoreName": "E-value", "accession": "PF00170.19", "start": 52, "score": 1.2e-21, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 108}}, {"startStyle": "jagged", "end": 106, "endStyle": "jagged", "aliStart": 56, "text": "MAF", "colour": "#FFD800", "aliEnd": 103, "start": 45, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 106, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 56, "scoreName": "E-value", "accession": "PF03131.15", "start": 45, "score": 0.00033999999999999997, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 103}}], "length": 114}

{"regions": [{"startStyle": "curved", "end": 124, "endStyle": "curved", "aliStart": 64, "text": "bZIP", "colour": "#009900", "aliEnd": 120, "start": 64, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 124, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 64, "scoreName": "E-value", "accession": "PF00170.19", "start": 64, "score": 1.4000000000000002e-21, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 120}}, {"startStyle": "jagged", "end": 118, "endStyle": "jagged", "aliStart": 68, "text": "MAF", "colour": "#FFD800", "aliEnd": 115, "start": 58, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 118, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 68, "scoreName": "E-value", "accession": "PF03131.15", "start": 58, "score": 0.00041, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 115}}], "length": 126}

TF Info Page for CREM (bZIP)

Conclusion

Description

Previous Annotations

DNA-Binding

Published Motif Data

Structure

Experimental History

External Contribution