The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:	cAMP responsive element modulator
Entrez Summary	TBA
Ensembl ID:	ENSG00000095794
External Link:
Interpro	IPR001630; IPR003102; IPR004827; ;
Protein Domain:
Protein: ENSP00000341875	DBD: bZIP	Other: pKID
Protein: ENSP00000265372	DBD: bZIP	Other: pKID
Protein: ENSP00000345384	DBD: bZIP	Other: pKID
Protein: ENSP00000346804	DBD: bZIP	Other: pKID
Protein: ENSP00000363858	DBD: bZIP	Other: pKID
Protein: ENSP00000420681	DBD: bZIP	Other:
Protein: ENSP00000417807	DBD: bZIP	Other:
Protein: ENSP00000344365	DBD: bZIP	Other:
Protein: ENSP00000349387	DBD: bZIP	Other:
Protein: ENSP00000420437	DBD: bZIP	Other:
Protein: ENSP00000418336	DBD: bZIP	Other:
Protein: ENSP00000419018	DBD: bZIP	Other:
Protein: ENSP00000417562	DBD: bZIP	Other:
Protein: ENSP00000417460	DBD: bZIP	Other:
Protein: ENSP00000419075	DBD: bZIP	Other:
Protein: ENSP00000417327	DBD: bZIP	Other:
Protein: ENSP00000403938	DBD: bZIP	Other: pKID
Protein: ENSP00000419810	DBD: bZIP	Other:
Protein: ENSP00000473519	DBD: bZIP	Other:
Protein: ENSP00000419924	DBD: bZIP	Other: pKID
Protein: ENSP00000417399	DBD: bZIP	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info	GO:0003700 sequence-specific DNA binding transcription factor activity IEA - GO_REF:0000002
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
PBM	Zoo_01		Inferred - Crem (78% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - CREB1 (75% AA Identity, Homo sapiens)
PBM	Mann2013		Inferred - Creb1 (75% AA Identity, Mus musculus)
PBM	Mann2013		Inferred - Creb1 (75% AA Identity, Mus musculus)
PBM	Zoo_01		Inferred - Creb1 (75% AA Identity, Mus musculus)
COMPILED	JASPAR		Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - CREB1 (75% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - CREB1 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ATF1 (73% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ATF1 (73% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ATF1 (73% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ATF1 (73% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - ATF1 (73% AA Identity, Homo sapiens)
PBM	Badis09		Inferred - Atf1 (72% AA Identity, Mus musculus)
PBM	Zoo_01		Inferred - Atf1 (72% AA Identity, Mus musculus)
HT-SELEX	Nitta2015		Inferred - CrebB-17A (66% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - CrebB-17A (66% AA Identity, Drosophila melanogaster)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for CREM (bZIP)