TF Info Page for CREM (bZIP)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: cAMP responsive element modulator
Entrez Summary This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000095794
External Link: CisBP
Interpro IPR001630; IPR003102; IPR004827; ;
Protein Domain: ENSP00000341875
Protein Domain: ENSP00000265372
Protein Domain: ENSP00000345384
Protein Domain: ENSP00000346804
Protein Domain: ENSP00000363858
Protein Domain: ENSP00000420681
Protein Domain: ENSP00000417807
Protein Domain: ENSP00000344365
Protein Domain: ENSP00000349387
Protein Domain: ENSP00000420437
Protein Domain: ENSP00000418336
Protein Domain: ENSP00000419018
Protein Domain: ENSP00000417562
Protein Domain: ENSP00000417460
Protein Domain: ENSP00000419075
Protein Domain: ENSP00000417327
Protein Domain: ENSP00000403938
Protein Domain: ENSP00000419810
Protein Domain: ENSP00000473519
Protein Domain: ENSP00000419924
Protein Domain: ENSP00000417399
Domain:
Protein: ENSP00000341875DBD: bZIPOther: pKID
Protein: ENSP00000265372DBD: bZIPOther: pKID
Protein: ENSP00000345384DBD: bZIPOther: pKID
Protein: ENSP00000346804DBD: bZIPOther: pKID
Protein: ENSP00000363858DBD: bZIPOther: pKID
Protein: ENSP00000420681DBD: bZIPOther:
Protein: ENSP00000417807DBD: bZIPOther:
Protein: ENSP00000344365DBD: bZIPOther:
Protein: ENSP00000349387DBD: bZIPOther:
Protein: ENSP00000420437DBD: bZIPOther:
Protein: ENSP00000418336DBD: bZIPOther:
Protein: ENSP00000419018DBD: bZIPOther:
Protein: ENSP00000417562DBD: bZIPOther:
Protein: ENSP00000417460DBD: bZIPOther:
Protein: ENSP00000419075DBD: bZIPOther:
Protein: ENSP00000417327DBD: bZIPOther:
Protein: ENSP00000403938DBD: bZIPOther: pKID
Protein: ENSP00000419810DBD: bZIPOther:
Protein: ENSP00000473519DBD: bZIPOther:
Protein: ENSP00000419924DBD: bZIPOther: pKID
Protein: ENSP00000417399DBD: bZIPOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IEA - GO_REF:0000002
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMZoo_01Inferred - Crem (78% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - CREB1 (75% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - CREB1 (75% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - CREB1 (75% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - CREB1 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - CREB1 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - CREB1 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - CREB1 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - CREB1 (75% AA Identity, Homo sapiens)
PBMMann2013Inferred - Creb1 (75% AA Identity, Mus musculus)
PBMMann2013Inferred - Creb1 (75% AA Identity, Mus musculus)
PBMZoo_01Inferred - Creb1 (75% AA Identity, Mus musculus)
COMPILEDJASPARInferred - CREB1 (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CREB1 (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CREB1 (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CREB1 (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CREB1 (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CREB1 (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CREB1 (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CREB1 (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CREB1 (75% AA Identity, Homo sapiens)
MiscHocoMocoInferred - CREB1 (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ATF1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ATF1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ATF1 (73% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ATF1 (73% AA Identity, Homo sapiens)
MiscHOMERInferred - ATF1 (73% AA Identity, Homo sapiens)
PBMBadis09Inferred - Atf1 (72% AA Identity, Mus musculus)
PBMZoo_01Inferred - Atf1 (72% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - CrebB-17A (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CrebB-17A (66% AA Identity, Drosophila melanogaster)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution