TF Info Page for ESR1 (Nuclear receptor)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467]
Entrez Summary NA
Ensembl ID: ENSG00000091831
External Link: CisBP
Interpro IPR000536; IPR001292; IPR001628; IPR001723; IPR008946; IPR024178; IPR024736; ;
Protein Domain: ENSP00000206249
Protein Domain: ENSP00000385373
Protein Domain: ENSP00000384064
Protein Domain: ENSP00000401995
Protein Domain: ENSP00000394721
Protein Domain: ENSP00000411105
Protein Domain: ENSP00000415934
Domain:
Protein: ENSP00000206249DBD: Nuclear Hormone ReceptorOther: ESR1_C, Hormone_recep, Oest_recep
Protein: ENSP00000385373DBD: Nuclear Hormone ReceptorOther: Oest_recep
Protein: ENSP00000384064DBD: Nuclear Hormone ReceptorOther: ESR1_C, Hormone_recep, Oest_recep
Protein: ENSP00000401995DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000394721DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000411105DBD: Nuclear Hormone ReceptorOther: Oest_recep
Protein: ENSP00000415934DBD: Nuclear Hormone ReceptorOther: Oest_recep

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:10908317 16636675
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:12047722
GO:0003700
sequence-specific DNA binding transcription factor activity
NAS - PMID:12552091
GO:0038052
estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
IDA - PMID:15831516 | IGI - PMID:18722177
GO:0043433
negative regulation of sequence-specific DNA binding transcription factor activity
IDA - PMID:10816575
GO:0051091
positive regulation of sequence-specific DNA binding transcription factor activity
IDA - PMID:10681512, PMID:9328340
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
ChIP-seqENCODEDirect
SELEXJASPARDirect
ChIP-seqmodENCODEDirect
ChIP-seqmodENCODEDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERDirect
PBMDREAM_contestInferred - Esr1 (100% AA Identity, Mus musculus)
PBMTF_EvolutionUnpublished DataInferred - Esr2 (92% AA Identity, Mus musculus)
ChIP-seqJASPARInferred - ESR2 (92% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ESR2 (92% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ESR2 (92% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ESR2 (92% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ESR2 (92% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Q6VU64_APLCA (81% AA Identity, Aplysia californica)

Structure

Structure PDB 1HCQ

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution