TF Info Page for ESR1 (Nuclear receptor)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467]
Entrez Summary This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
Ensembl ID: ENSG00000091831
External Link: CisBP
Interpro IPR000536; IPR001292; IPR001628; IPR001723; IPR008946; IPR024178; IPR024736; ;
Protein Domain: ENSP00000206249
Protein Domain: ENSP00000385373
Protein Domain: ENSP00000384064
Protein Domain: ENSP00000401995
Protein Domain: ENSP00000394721
Protein Domain: ENSP00000411105
Protein Domain: ENSP00000415934
Domain:
Protein: ENSP00000206249DBD: Nuclear Hormone ReceptorOther: ESR1_C, Hormone_recep, Oest_recep
Protein: ENSP00000385373DBD: Nuclear Hormone ReceptorOther: Oest_recep
Protein: ENSP00000384064DBD: Nuclear Hormone ReceptorOther: ESR1_C, Hormone_recep, Oest_recep
Protein: ENSP00000401995DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000394721DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000411105DBD: Nuclear Hormone ReceptorOther: Oest_recep
Protein: ENSP00000415934DBD: Nuclear Hormone ReceptorOther: Oest_recep

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:10908317 16636675
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:12047722
GO:0003700
sequence-specific DNA binding transcription factor activity
NAS - PMID:12552091
GO:0038052
estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
IDA - PMID:15831516 | IGI - PMID:18722177
GO:0043433
negative regulation of sequence-specific DNA binding transcription factor activity
IDA - PMID:10816575
GO:0051091
positive regulation of sequence-specific DNA binding transcription factor activity
IDA - PMID:10681512, PMID:9328340
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
ChIP-seqENCODEDirect
SELEXJASPARDirect
ChIP-seqmodENCODEDirect
ChIP-seqmodENCODEDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERDirect
PBMDREAM_contestInferred - Esr1 (100% AA Identity, Mus musculus)
PBMTF_EvolutionUnpublished DataInferred - Esr2 (92% AA Identity, Mus musculus)
ChIP-seqJASPARInferred - ESR2 (92% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ESR2 (92% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ESR2 (92% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ESR2 (92% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ESR2 (92% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Q6VU64_APLCA (81% AA Identity, Aplysia californica)

Structure

Structure PDB 1HCQ

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution