TF Info Page for ESR1 (Nuclear receptor)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description
| Description: | estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467] | |||||||||||||||||||||
| Entrez Summary | This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain. [provided by RefSeq, Jul 2020] | |||||||||||||||||||||
| Ensembl ID: | ENSG00000091831 | |||||||||||||||||||||
| External Link: | CisBP | |||||||||||||||||||||
| Interpro | IPR000536; IPR001292; IPR001628; IPR001723; IPR008946; IPR024178; IPR024736; ; | |||||||||||||||||||||
| Protein Domain: | ENSP00000206249 | |||||||||||||||||||||
| Protein Domain: | ENSP00000385373 | |||||||||||||||||||||
| Protein Domain: | ENSP00000384064 | |||||||||||||||||||||
| Protein Domain: | ENSP00000401995 | |||||||||||||||||||||
| Protein Domain: | ENSP00000394721 | |||||||||||||||||||||
| Protein Domain: | ENSP00000411105 | |||||||||||||||||||||
| Protein Domain: | ENSP00000415934 | |||||||||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:10908317 16636675 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:12047722 GO:0003700 sequence-specific DNA binding transcription factor activity NAS - PMID:12552091 GO:0038052 estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA - PMID:15831516 | IGI - PMID:18722177 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IDA - PMID:10816575 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IDA - PMID:10681512, PMID:9328340 |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |