TF Info Page for MECOM (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain

Description

Description: MDS1 and EVI1 complex locus [Source:HGNC Symbol;Acc:HGNC:3498]
Entrez Summary The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Ensembl ID: ENSG00000085276
External Link: CisBP
Interpro IPR001214; IPR007087; IPR015880; ;
Protein Domain: ENSP00000264674
Protein Domain: ENSP00000394302
Protein Domain: ENSP00000420466
Protein Domain: ENSP00000417922
Protein Domain: ENSP00000419770
Protein Domain: ENSP00000418689
Protein Domain: ENSP00000419757
Protein Domain: ENSP00000420072
Protein Domain: ENSP00000486104
Protein Domain: ENSP00000419995
Domain:
Protein: ENSP00000264674DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000394302DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000420466DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000417922DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000419770DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000418689DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000419757DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000420072DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000486104DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000419995DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:15889140
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:19767769
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
SELEXJASPARInferred - Mecom (97% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution