TF Info Page for NCOA1 (bHLH)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 2 Obligate heteromer No motif NCOA1/2/3 all have been tested on PBMs and HT-SELEX without yielding a motif. All are co-activators, collectively suggesting they might be obligate heteromers.

Description

Description: nuclear receptor coactivator 1 [Source:HGNC Symbol;Acc:HGNC:7668]
Entrez Summary The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000084676
External Link: CisBP
Interpro IPR000014; IPR009110; IPR010011; IPR011598; IPR013767; IPR014920; IPR014935; IPR017426;
Protein Domain: ENSP00000288599
Protein Domain: ENSP00000320940
Protein Domain: ENSP00000379197
Protein Domain: ENSP00000385195
Domain:
Protein: ENSP00000288599DBD: bHLHOther: DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA
Protein: ENSP00000320940DBD: bHLHOther: DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA
Protein: ENSP00000379197DBD: bHLHOther: DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA
Protein: ENSP00000385195DBD: bHLHOther: DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS_11,

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate_Transcription Factor Binding
tf co-factor binding_TF PPI_
PMIDS:9192892
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
c
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution