Assessment | Binding Mode | Motif Status | Notes | Comments |
---|---|---|---|---|
Known motif | 1 Monomer or homomultimer | In vivo/Misc source |
Description: | grainyhead like transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:2799] | |||||||||
Entrez Summary | #!usr/local/bin/perl ?> The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).[provided by RefSeq, Mar 2009] | |||||||||
Ensembl ID: | ENSG00000083307 | |||||||||
External Link: | CisBP | |||||||||
Interpro | IPR007604; ; | |||||||||
Protein Domain: | ENSP00000251808 | |||||||||
Protein Domain: | ENSP00000379260 | |||||||||
Protein Domain: | ENSP00000430473 | |||||||||
Domain: |
|
Source | Annotation |
TF-CAT classification |
Indeterminate - There is no evidence for or against this genes role as a TF___ PMIDS:0 |
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
CisBP considers it as a TF? | Yes |
TFclass considers it as a TF? | Yes |
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
GO-Info |
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IDA - PMID:23814079 GO:0003700 sequence-specific DNA binding transcription factor activity ISS - GO_REF:0000024 |
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
TF has conditional DNA-binding requirements |