The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:	myocyte enhancer factor 2C [Source:HGNC Symbol;Acc:HGNC:6996]
Entrez Summary	TBA
Ensembl ID:	ENSG00000081189
External Link:	T111434_1.02
Interpro	IPR002100; IPR022102;
Protein Domain:
Protein: ENSP00000340874	DBD: MADS box	Other: HJURP_C
Protein: ENSP00000389610	DBD: MADS box	Other: HJURP_C
Protein: ENSP00000396219	DBD: MADS box	Other: HJURP_C
Protein: ENSP00000421925	DBD: MADS box	Other: HJURP_C
Protein: ENSP00000487184	DBD: MADS box	Other: HJURP_C
Protein: ENSP00000487311	DBD: MADS box	Other:
Protein: ENSP00000427163	DBD: MADS box	Other: HJURP_C
Protein: ENSP00000424331	DBD: MADS box	Other: HJURP_C
Protein: ENSP00000427309	DBD: MADS box	Other:
Protein: ENSP00000490525	DBD: MADS box	Other:
Protein: ENSP00000490473	DBD: MADS box	Other: HJURP_C
Protein: ENSP00000489865	DBD: MADS box	Other: HJURP_C
Protein: ENSP00000490630	DBD: MADS box	Other: HJURP_C
Protein: ENSP00000490354	DBD: MADS box	Other: HJURP_C
Protein: ENSP00000490241	DBD: MADS box	Other: HJURP_C

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity ISS - PMID:21610032 GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity IDA - PMID:8455629 GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:15486975 GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv IEA - GO_REF:0000019 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:16043483
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Jolma2010		Direct
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
ChIP-seq	ENCODE		Direct
ChIP-seq	JASPAR		Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
Misc	HOMER		Direct
ChIP-seq	ENCODE		Inferred - MEF2A (97% AA Identity, Homo sapiens)
SELEX	JASPAR		Inferred - MEF2A (97% AA Identity, Homo sapiens)
ChIP-seq	modENCODE		Inferred - MEF2A (97% AA Identity, Homo sapiens)
ChIP-seq	modENCODE		Inferred - MEF2A (97% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MEF2A (97% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MEF2A (97% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MEF2A (97% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MEF2A (97% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MEF2A (97% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MEF2A (97% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MEF2A (97% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MEF2A (97% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MEF2A (97% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MEF2A (97% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MEF2A (97% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MEF2A (97% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - MEF2A (97% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - Mef2a (97% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - MEF2D (93% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - MEF2D (93% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MEF2D (93% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - MEF2D (93% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - MEF2B (91% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - MEF2B (91% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - MEF2B (91% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - MEF2B (91% AA Identity, Homo sapiens)
ChIP-seq	modENCODE		Inferred - Mef2 (87% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - Mef2b (87% AA Identity, Mus musculus)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for MEF2C (MADS box)