Conclusion
Assessment
Binding Mode
Motif Status
Notes
Comments
Known motif
1 Monomer or homomultimer
High-throughput in vitro
Description
Description:
myocyte enhancer factor 2C [Source:HGNC Symbol;Acc:HGNC:6996]
Entrez Summary
TBA
Ensembl ID:
ENSG00000081189
External Link:
T111434_1.02
Interpro
IPR002100 ; IPR022102 ;
Protein Domain:
Protein: ENSP00000340874DBD: MADS boxOther: HJURP_CProtein: ENSP00000389610DBD: MADS boxOther: HJURP_CProtein: ENSP00000396219DBD: MADS boxOther: HJURP_CProtein: ENSP00000421925DBD: MADS boxOther: HJURP_CProtein: ENSP00000487184DBD: MADS boxOther: HJURP_CProtein: ENSP00000487311DBD: MADS boxOther: Protein: ENSP00000427163DBD: MADS boxOther: HJURP_CProtein: ENSP00000424331DBD: MADS boxOther: HJURP_CProtein: ENSP00000427309DBD: MADS boxOther: Protein: ENSP00000490525DBD: MADS boxOther: Protein: ENSP00000490473DBD: MADS boxOther: HJURP_CProtein: ENSP00000489865DBD: MADS boxOther: HJURP_CProtein: ENSP00000490630DBD: MADS boxOther: HJURP_CProtein: ENSP00000490354DBD: MADS boxOther: HJURP_CProtein: ENSP00000490241DBD: MADS boxOther: HJURP_C
Previous Annotations
Source
Annotation
TF-CAT classification
No PMIDS:
Vaquerizas 2009 TF classification
"a " Has direct evidence of TF function;
"b " Has evidence for an orthologous TF;
"c " contains likely DBDs, but has no functional evidence;
"x " is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other " category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity ISS - PMID:21610032 GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity IDA - PMID:8455629 GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:15486975 GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv IEA - GO_REF:0000019 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:16043483
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements
DNA-Binding
Published Motif Data
Structure
Experimental History
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