TF Info Page for MEF2C (MADS box)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: myocyte enhancer factor 2C [Source:HGNC Symbol;Acc:HGNC:6996]
Entrez Summary This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
Ensembl ID: ENSG00000081189
External Link: CisBP
Interpro IPR002100; IPR022102;
Protein Domain: ENSP00000340874
Protein Domain: ENSP00000389610
Protein Domain: ENSP00000396219
Protein Domain: ENSP00000421925
Protein Domain: ENSP00000487184
Protein Domain: ENSP00000487311
Protein Domain: ENSP00000427163
Protein Domain: ENSP00000424331
Protein Domain: ENSP00000427309
Protein Domain: ENSP00000490525
Protein Domain: ENSP00000490473
Protein Domain: ENSP00000489865
Protein Domain: ENSP00000490630
Protein Domain: ENSP00000490354
Protein Domain: ENSP00000490241
Domain:
Protein: ENSP00000340874DBD: MADS boxOther: HJURP_C
Protein: ENSP00000389610DBD: MADS boxOther: HJURP_C
Protein: ENSP00000396219DBD: MADS boxOther: HJURP_C
Protein: ENSP00000421925DBD: MADS boxOther: HJURP_C
Protein: ENSP00000487184DBD: MADS boxOther: HJURP_C
Protein: ENSP00000487311DBD: MADS boxOther:
Protein: ENSP00000427163DBD: MADS boxOther: HJURP_C
Protein: ENSP00000424331DBD: MADS boxOther: HJURP_C
Protein: ENSP00000427309DBD: MADS boxOther:
Protein: ENSP00000490525DBD: MADS boxOther:
Protein: ENSP00000490473DBD: MADS boxOther: HJURP_C
Protein: ENSP00000489865DBD: MADS boxOther: HJURP_C
Protein: ENSP00000490630DBD: MADS boxOther: HJURP_C
Protein: ENSP00000490354DBD: MADS boxOther: HJURP_C
Protein: ENSP00000490241DBD: MADS boxOther: HJURP_C

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
ISS - PMID:21610032
GO:0000983
RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
IDA - PMID:8455629
GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:15486975
GO:0001205
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv
IEA - GO_REF:0000019
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:16043483
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2010Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
ChIP-seqENCODEDirect
ChIP-seqJASPARDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERDirect
ChIP-seqENCODEInferred - MEF2A (97% AA Identity, Homo sapiens)
SELEXJASPARInferred - MEF2A (97% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - MEF2A (97% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
MiscHocoMocoInferred - MEF2A (97% AA Identity, Homo sapiens)
MiscHOMERInferred - Mef2a (97% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - MEF2D (93% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MEF2D (93% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2D (93% AA Identity, Homo sapiens)
MiscHocoMocoInferred - MEF2D (93% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - MEF2B (91% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - MEF2B (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MEF2B (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MEF2B (91% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - Mef2 (87% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - Mef2b (87% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution