TF Info Page for MEF2C (MADS box)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: myocyte enhancer factor 2C [Source:HGNC Symbol;Acc:HGNC:6996]
Entrez Summary NA
Ensembl ID: ENSG00000081189
External Link: CisBP
Interpro IPR002100; IPR022102;
Protein Domain: ENSP00000340874
Protein Domain: ENSP00000389610
Protein Domain: ENSP00000396219
Protein Domain: ENSP00000421925
Protein Domain: ENSP00000487184
Protein Domain: ENSP00000487311
Protein Domain: ENSP00000427163
Protein Domain: ENSP00000424331
Protein Domain: ENSP00000427309
Protein Domain: ENSP00000490525
Protein Domain: ENSP00000490473
Protein Domain: ENSP00000489865
Protein Domain: ENSP00000490630
Protein Domain: ENSP00000490354
Protein Domain: ENSP00000490241
Domain:
Protein: ENSP00000340874DBD: MADS boxOther: HJURP_C
Protein: ENSP00000389610DBD: MADS boxOther: HJURP_C
Protein: ENSP00000396219DBD: MADS boxOther: HJURP_C
Protein: ENSP00000421925DBD: MADS boxOther: HJURP_C
Protein: ENSP00000487184DBD: MADS boxOther: HJURP_C
Protein: ENSP00000487311DBD: MADS boxOther:
Protein: ENSP00000427163DBD: MADS boxOther: HJURP_C
Protein: ENSP00000424331DBD: MADS boxOther: HJURP_C
Protein: ENSP00000427309DBD: MADS boxOther:
Protein: ENSP00000490525DBD: MADS boxOther:
Protein: ENSP00000490473DBD: MADS boxOther: HJURP_C
Protein: ENSP00000489865DBD: MADS boxOther: HJURP_C
Protein: ENSP00000490630DBD: MADS boxOther: HJURP_C
Protein: ENSP00000490354DBD: MADS boxOther: HJURP_C
Protein: ENSP00000490241DBD: MADS boxOther: HJURP_C

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
ISS - PMID:21610032
GO:0000983
RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
IDA - PMID:8455629
GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:15486975
GO:0001205
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv
IEA - GO_REF:0000019
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:16043483
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2010Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
ChIP-seqENCODEDirect
ChIP-seqJASPARDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERDirect
ChIP-seqENCODEInferred - MEF2A (97% AA Identity, Homo sapiens)
SELEXJASPARInferred - MEF2A (97% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - MEF2A (97% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2A (97% AA Identity, Homo sapiens)
MiscHocoMocoInferred - MEF2A (97% AA Identity, Homo sapiens)
MiscHOMERInferred - Mef2a (97% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - MEF2D (93% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MEF2D (93% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - MEF2D (93% AA Identity, Homo sapiens)
MiscHocoMocoInferred - MEF2D (93% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - MEF2B (91% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - MEF2B (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MEF2B (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MEF2B (91% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - Mef2 (87% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - Mef2b (87% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution