TF Info Page for TP73 (p53)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source


Description: tumor protein p73 [Source:HGNC Symbol;Acc:HGNC:12003]
Entrez Summary This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
Ensembl ID: ENSG00000078900
External Link: CisBP
Interpro IPR001660; IPR002117; IPR008967; IPR010991; IPR011510; IPR011615; IPR013761; ;
Protein Domain: ENSP00000367529
Protein Domain: ENSP00000367534
Protein Domain: ENSP00000367537
Protein Domain: ENSP00000367545
Protein Domain: ENSP00000367539
Protein: ENSP00000367529DBD: p53Other: P53_tetramer
Protein: ENSP00000367534DBD: p53Other: P53_tetramer
Protein: ENSP00000367537DBD: p53Other: P53_tetramer, SAM_1, SAM_2
Protein: ENSP00000367545DBD: p53Other: P53_tetramer, SAM_1, SAM_2
Protein: ENSP00000367539DBD: p53Other: P53_tetramer, SAM_1, SAM_2

Previous Annotations

Source Annotation
TF-CAT classification Indeterminate - There is no evidence for or against this genes role as a TF___
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IDA - PMID:24652652
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:16343436
sequence-specific DNA binding transcription factor activity
IDA - PMID:15678106
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect


Structure PDB 3VD0

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution