The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	In vivo/Misc source

Description

Description:	tumor protein p73 [Source:HGNC Symbol;Acc:HGNC:12003]
Entrez Summary	TBA
Ensembl ID:	ENSG00000078900
External Link:
Interpro	IPR001660; IPR002117; IPR008967; IPR010991; IPR011510; IPR011615; IPR013761; ;
Protein Domain:
Protein: ENSP00000367529	DBD: p53	Other: P53_tetramer
Protein: ENSP00000367534	DBD: p53	Other: P53_tetramer
Protein: ENSP00000367537	DBD: p53	Other: P53_tetramer, SAM_1, SAM_2
Protein: ENSP00000367545	DBD: p53	Other: P53_tetramer, SAM_1, SAM_2
Protein: ENSP00000367539	DBD: p53	Other: P53_tetramer, SAM_1, SAM_2

Previous Annotations

Source	Annotation
TF-CAT classification	Indeterminate - There is no evidence for or against this genes role as a TF___ PMIDS:0
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IDA - PMID:24652652 GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:16343436 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:15678106
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
ChIP-seq	hmCHIP		Direct
ChIP-seq	hmCHIP		Direct
ChIP-seq	hmCHIP		Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct

Structure

Structure	PDB	3VD0

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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{"regions": [{"startStyle": "curved", "end": 309, "endStyle": "curved", "aliStart": 114, "text": "P53", "colour": "#228B22", "aliEnd": 309, "start": 113, "href": "http://pfam.xfam.org/family/PF00870.16", "type": "pfama", "display": "true", "metadata": {"end": 309, "description": "This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.", "database": "PfamA", "aliStart": 114, "scoreName": "E-value", "accession": "PF00870.16", "start": 113, "score": 4.6999999999999985e-113, "identifier": "P53 DNA-binding domain", "type": "DBD", "aliEnd": 309}}, {"startStyle": "straight", "end": 384, "endStyle": "straight", "aliStart": 345, "text": "P53_tetramer", "colour": "#9999ff", "aliEnd": 383, "start": 345, "href": "http://pfam.xfam.org/family/PF07710.9", "type": "pfama", "display": "true", "metadata": {"end": 384, "description": NaN, "database": "PfamA", "aliStart": 345, "scoreName": "E-value", "accession": "PF07710.9", "start": 345, "score": 3.3999999999999997e-19, "identifier": "P53 tetramerisation motif", "type": "DBD", "aliEnd": 383}}, {"startStyle": "straight", "end": 549, "endStyle": "straight", "aliStart": 486, "text": "SAM_2", "colour": "#9999ff", "aliEnd": 549, "start": 485, "href": "http://pfam.xfam.org/family/PF07647.15", "type": "pfama", "display": "true", "metadata": {"end": 549, "description": NaN, "database": "PfamA", "aliStart": 486, "scoreName": "E-value", "accession": "PF07647.15", "start": 485, "score": 7.5e-10, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 549}}, {"startStyle": "jagged", "end": 549, "endStyle": "straight", "aliStart": 492, "text": "SAM_1", "colour": "#9999ff", "aliEnd": 548, "start": 488, "href": "http://pfam.xfam.org/family/PF00536.28", "type": "pfama", "display": "true", "metadata": {"end": 549, "description": "It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.", "database": "PfamA", "aliStart": 492, "scoreName": "E-value", "accession": "PF00536.28", "start": 488, "score": 0.0005, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 548}}], "length": 637}

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TF Info Page for TP73 (p53)