TF Info Page for TP73 (p53)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | In vivo/Misc source |
Description
| Description: | tumor protein p73 [Source:HGNC Symbol;Acc:HGNC:12003] | |||||||||||||||
| Entrez Summary | This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011] | |||||||||||||||
| Ensembl ID: | ENSG00000078900 | |||||||||||||||
| External Link: | CisBP | |||||||||||||||
| Interpro | IPR001660; IPR002117; IPR008967; IPR010991; IPR011510; IPR011615; IPR013761; ; | |||||||||||||||
| Protein Domain: | ENSP00000367529 | |||||||||||||||
| Protein Domain: | ENSP00000367534 | |||||||||||||||
| Protein Domain: | ENSP00000367537 | |||||||||||||||
| Protein Domain: | ENSP00000367545 | |||||||||||||||
| Protein Domain: | ENSP00000367539 | |||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
Indeterminate - There is no evidence for or against this genes role as a TF___ PMIDS:0 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IDA - PMID:24652652 GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:16343436 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:15678106 |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |