TF Info Page for NFKB2 (Rel)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro


Description: nuclear factor kappa B subunit 2 [Source:HGNC Symbol;Acc:HGNC:7795]
Entrez Summary This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Ensembl ID: ENSG00000077150
External Link: CisBP
Interpro IPR000451; IPR000488; IPR002110; IPR002909; IPR008967; IPR011029; IPR011539; IPR014756; IPR020683; IPR030492;
Protein Domain: ENSP00000189444
Protein Domain: ENSP00000358983
Protein Domain: ENSP00000410256
Protein Domain: ENSP00000471586
Protein: ENSP00000189444DBD: RHDOther: Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer
Protein: ENSP00000358983DBD: RHDOther: Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer
Protein: ENSP00000410256DBD: RHDOther: Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer
Protein: ENSP00000471586DBD: RHDOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:12835724
sequence-specific DNA binding transcription factor activity
TAS - PMID:1760839, PMID:1876189
positive regulation of NF-kappaB transcription factor activity
TAS - Reactome:R-HSA-445989
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence


Structure PDB 1A3Q

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution