TF Info Page for NFKB2 (Rel)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description
| Description: | nuclear factor kappa B subunit 2 [Source:HGNC Symbol;Acc:HGNC:7795] | ||||||||||||
| Entrez Summary | This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] | ||||||||||||
| Ensembl ID: | ENSG00000077150 | ||||||||||||
| External Link: | CisBP | ||||||||||||
| Interpro | IPR000451; IPR000488; IPR002110; IPR002909; IPR008967; IPR011029; IPR011539; IPR014756; IPR020683; IPR030492; | ||||||||||||
| Protein Domain: | ENSP00000189444 | ||||||||||||
| Protein Domain: | ENSP00000358983 | ||||||||||||
| Protein Domain: | ENSP00000410256 | ||||||||||||
| Protein Domain: | ENSP00000471586 | ||||||||||||
| Domain: |
|
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:8360178 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:12835724 GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:1760839, PMID:1876189 GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS - Reactome:R-HSA-445989 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |