TF Info Page for BAZ2A (MBD; AT hook)


Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 3 Low specificity DNA-binding protein No motif Component of the silencing nucleolar remodelling complex (NoRC) (PMID: 22368283)


Description: bromodomain adjacent to zinc finger domain 2A [Source:HGNC Symbol;Acc:HGNC:962]
Entrez Summary NA
Ensembl ID: ENSG00000076108
External Link: CisBP
Interpro IPR001487; IPR001739; IPR001965; IPR004022; IPR011011; IPR016177; IPR017956; IPR018359; IPR018500; IPR018501; IPR019787; ;
Protein Domain: ENSP00000368754
Protein Domain: ENSP00000448760
Protein Domain: ENSP00000446880
Protein Domain: ENSP00000447248
Protein Domain: ENSP00000447941
Protein Domain: ENSP00000449496
Protein Domain: ENSP00000449473
Protein: ENSP00000368754DBD: Methyl-CpG DNA-bindingOther: Bromodomain, DDT, PHD, WHIM1, WSD
Protein: ENSP00000448760DBD: Methyl-CpG DNA-bindingOther: Bromodomain, PHD, WSD
Protein: ENSP00000446880DBD: Methyl-CpG DNA-bindingOther: Bromodomain, DDT, PHD, WHIM1, WSD
Protein: ENSP00000447248DBD: Methyl-CpG DNA-bindingOther:
Protein: ENSP00000447941DBD: Methyl-CpG DNA-bindingOther: Bromodomain, DDT, PHD, WHIM1, WSD
Protein: ENSP00000449496DBD: Methyl-CpG DNA-bindingOther:
Protein: ENSP00000449473DBD: Methyl-CpG DNA-bindingOther:

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution